Nifedipine A Review of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy, in Ischaemic Heart Disease, Hypertension and Related Cardiovascular Disorders

Pharmacokinetics, bioavailability, metabolism and acute and chronic antihypertensive effects of nitrendipine in patients with chronic renal failure and moderate to severe hypertension.

“…Compared with nifedipine it has a of 20 to 40 mg nitrendipine suffices to lower blood longer terminal elimination half-life (nitrendipine: 8 h; pressure effectively. nifedipine: 2 h) Sorkin et al, 1985).…”

Vasodilators during cerebral aneurysm surgery

“…Recently, it has been shown that calcium channel blockers also affect the cerebral circulation. Nicardipine, 107,108 nimodipine, 109 verapami1107 and diltiazem "~ increased cerebral blood flow in animals. Nicardipine is a watersoluble, photoresistant di-hydropyridine calcium channel blocker that causes potent systemic and coronary vasodilatation but does not result in negative inotropic, chronotropic, or dromotropic effects.…”

Comparison of once daily atenolol, nitrendipine and their combination in mild to moderate essential hypertension.

“…The 0-adrenoceptor antagonist will tend to control any initial reflex tachycardia caused by the calcium antagonist, while at the same time the calcium antagonist may ameliorate any tendency of the ,-adrenoceptor antagonist to increase peripheral vascular resistance (Sorkin et al, 1985). Moreover, because of their different modes of action, greater reductions in blood pressure are seen with such combinations than with either drug alone (Daniels et al, 1986) and low-dose combinations are not only efficacious but well tolerated (Maclean et al, 1988;Nifedipine-Atenolol Study Review Committee, 1988).…”