NiFe-Layered Double Hydroxide Sheets as an Efficient Electrochemical Biosensing Platform

Abstract

The maximum allowed limits of chlorpromazine (CPZ) established by Food and Drug Administration (FDA) for children aged between 1 and 5 years is 0.125 mM and between 6 to 12 years is 0.235 mM. However, excess consumption of CPZ beyond these permissible limit cause adverse health effects. In order to detect CPZ, herein, we employ NiFe-layered double hydroxide sheets modified glassy carbon electrode (GC/NiFe LDH). The GC/NiFe LDH electrode exhibited a good electrocatalytic activity towards CPZ detection at a less working potential even in the presence of interferents such as ascorbic acid, uric acid, glucose, sucrose, fructose and acetaminophen. The anodic peak observed at 614 mV (vs. Ag/AgCl) corresponds to the oxidation of CPZ and the proposed platform exhibited an excellent linearity in the range 75 μM to 1.0 mM. Further, the GC/NiFe LDH electrode exhibited an excellent sensitivity (1.05 μA μM −1 ), repeatability (0.86% RSD), reproducibility (1.54% RSD) and limit of detection (1.23 μM).

Role of Transition Metals in Layered Double Hydroxides for Differentiating the Oxygen Evolution and Nonenzymatic Glucose Sensing

“…Tao et al reported the use of NiFe-LDH for sensing hydrogen peroxide, with a sensitivity of 1704 μA mM –1 cm –2 . Nesakumar et al explored the use of NiFe-LDH for chlorpromazine sensing . Lu et al reported the use of NiFe-LDH (3:1) in the electrochemical sensing of glucose molecules, but the oxygen evolution reaction (OER) contribution has not been discussed .…”

“…17 Nesakumar et al explored the use of NiFe-LDH for chlorpromazine sensing. 20 Lu et al reported the use of NiFe-LDH (3:1) in the electrochemical sensing of glucose molecules, but the oxygen evolution reaction (OER) contribution has not been discussed. 18 In this class of materials, it is imperative to note that the onset potential for oxygen evolution and the glucose oxidation potential are close such that they might have an impact on glucose sensing.…”

A Facile Electrochemical Sensor Based on NiO-ZnO/MWCNT-COOH Modified GCE for Simultaneous Quantification of Imatinib and Itraconazole

“…In recent years, metals and metal oxides have been extensively studied in the sensing fields, such as Pt, Au, Ni, Fe, Ag, ZnO, NiO, TiO 2 and Fe 2 O 3 . 21,22 Among them, ZnO and NiO have attracted extensive attention due to their environmental friendliness, high specific surface area and superior electrochemical properties. [23][24][25] The composite of NiO-ZnO, based on an incorporation of p-type semiconductor NiO and n-type semiconductor ZnO, combines the different properties of individual ingredient and enhance sensing performance through their cooperative effect.…”

NiFe-Layered Double Hydroxides as a Novel Hole Repository Layer for Reinforced Visible-Light Photocatalytic Activity for Degradation of Refractory Pollutants

“…Layered double hydroxides (LDHs), a kind of extraordinary two-dimensional (2D)-layered nanomaterials, have obtained wide attention by virtue of their large charge density along prep the 2D backfin space height in application scenarios of photocatalysts, thermocatalysts, and electrocatalysts. − Wang et al reported MoO 3 /Zn-Al LDHs composites as photocatalysts for photocatalytic elimination of tetracycline target pollutants . Ao et al reported that the MB target pollutant molecules can be completely eliminated using three-dimensional (3D) flower-like Ag 2 CO 3 /Mg-Al LDHs photocatalysts within 40 min under visible-light irradiation .…”