Nicotinic Acid Therapy of Dermatitis Herpetiformis

Combination therapy with nicotinamide and tetracyclines for cicatricial pemphigoid: further support for its efficacy

“…In addition, it inhibits antigen‐induced lymphocyte proliferation and transformation, 14 neutrophil and eosinophil chemotaxis and secretion, 10 mast cell histamine release and is a free radical scavenger. Such properties may account for its apparent beneficial effects in a wide variety of immunological and inflammatory skin diseases; thus a number of these have benefited from high dose (300–2500 mg/day) therapy, particularly dermatitis herpetiformis, 15 erythema elevatum diutinum, 16 generalized granuloma annulare, 17 various immunobullous diseases, 6 –12 polymorphic light eruption, 18 and necrobiosis lipoidica 19 . Cicatricial pemphigoid is also an immunological mucosal and cutaneous disorder, the in vivo deposition of immunoglobulins and complement at the basement membrane zone with the presence of circulating basement membrane zone antibodies providing the evidence for an autoimmune aetiology.…”

Dermatitis herpetiformis effectively treated with heparin, tetracycline and nicotinamide

“…Alternative therapies for DH patients who are intolerant of dapsone and other supha drugs include cholestyramine, sodium cromoglycate, tetracycline and nicotinamide, 2 sulphasalazine, 3 heparin 4 cyclosporin 5 and nicotinic acid. 6 …”

Dermatitis herpetiformis

“…In uncontrolled studies and case reports, cyclosporine, colchicine, heparin, tetracycline, and nicotinamide have all been claimed to be effective in patients with DH. [44][45][46][47][48][49] Antihistamines may play a limited, adjunctive role to control DH-associated pruritus. 1 The care of patients with DH should involve a team approach that includes a dermatologist, gastroenterologist, and nutritionist.…”