Nicotinic Acetylcholine Receptors of PC12 Cells

Mussina, Kamilla; Toktarkhanova, Dana; Filchakova, Olena

doi:10.1007/s10571-020-00846-x

Cited by 9 publications

(4 citation statements)

References 168 publications

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“…Both human progenitor and chromaffin cells express the cholinergic receptor nAChRs α7 (encoded by the nicotinic acetylcholine receptor gene CHRNA7), suggesting that progenitor cells are of cholinergic nature. nAChRα7 is a critical component for the cholinergic system mediating ligand-gated ion channel activation of calcium dependent signaling pathways [25], and is involved in the response to cortisol and oxidative stress [26,27]. As this post-natal progenitor population of chromaffin cells does not express the SCP markers SOX10, S100B, nor FOXD3 and is not present in the mouse adrenal gland, it is possible that it is unique to humans.…”

Section: Discussionmentioning

confidence: 99%

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors

Bedoya-Reina

Arceo

et al. 2021

Preprint

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Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. We studied single-cell and single-nuclei transcriptomes of neuroblastoma with different clinical risk groups and stages, including healthy adrenal gland. We compared tumor cell populations with embryonic mouse sympatho-adrenal derivatives, and post-natal human adrenal gland. We provide evidence that low and high-risk neuroblastoma have different cell identities, representing two disease entities. Low-risk neuroblastoma presents a transcriptome that resembles sympatho- and chromaffin cells, whereas malignant cells enriched in high-risk neuroblastoma resembles an unknown subtype of TRKB+ cholinergic progenitor population identified in human post-natal gland. Analyses of these populations revealed different gene expression programs for worst and better survival in correlation with age at diagnosis. Our findings reveal two cellular identities and a composition of human neuroblastoma tumors reflecting clinical heterogeneity and outcome.

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Section: Discussionmentioning

confidence: 99%

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors

Bedoya-Reina

Arceo

et al. 2021

Preprint

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“…The released catecholamines were measured using PC12 cells. 44,45 All procedures (including incubation, washing, and the detection of drug release) were performed at room temperature in 1 mL of Hank's balanced salt solution. Catecholamine levels were measured using a commercially available ELISA kit (Jining Biotechnology, China) according to the manufacturer's instructions.…”

Section: 3mentioning

confidence: 99%

3D printing of customized bioceramics for promoting bone tissue regeneration by regulating sympathetic nerve behavior

Su,

Guo,

Gui

et al. 2024

J. Mater. Chem. B

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“…Ion channel-coupled receptors are a class of macromolecules that are ion channels and have ligand-binding sites, which can act as ion channels and signal transducers. Different from ion channels controlled by potential and chemically modified ion channels, the opening and closing of these ion channels are directly controlled by ligands, which are mainly neurotransmitters [ 45 ]. Ion-channel receptors can be cation channels, such as those for acetylcholine, glutamate, and serotonin, or anionic channels, such as those for glycine and gamma-aminobutyric acid [ 46 ].…”

Section: Membrane Receptor Proteinsmentioning

confidence: 99%

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

2021

Membranes

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Normal substrate transport and signal transmission are the premise to ensure the health of biological somatic cells. Therefore; a comprehensive understanding of the molecular mechanism of intercellular substrate transport is of great significance for clinical treatment. In order to better understand the membrane protein through its interaction with receptors, to help maintain a healthy cell and the molecular mechanisms of disease, in this paper, we seek to clarify, first of all, the recognition mechanism for different types of membrane protein receptors; pathogen invasion using the transport pathway involved in the membrane; and the latest specific target sites of various kinds of membrane transport carriers; to provide an explanation and summary of the system. Secondly; the downstream receptor proteins and specific substrates of different membrane transporters were classified systematically; the functional differences of different subclasses and their relationship with intracellular transport disorders were analyzed to further explore the potential relationship between cell transport disorders and diseases. Finally, the paper summarizes the use of membrane transporter-specific targets for drug design and development from the latest research results; it points out the transporter-related results in disease treatment; the application prospects and the direction for drug development and disease treatment providing a new train of thought; also for disease-specific targeted therapy, it provides a certain reference value.

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Nicotinic Acetylcholine Receptors of PC12 Cells

Cited by 9 publications

References 168 publications

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors

3D printing of customized bioceramics for promoting bone tissue regeneration by regulating sympathetic nerve behavior

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

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