Nicotinic acetylcholine receptors in the autonomic control of bladder function

Biasi, Mariella De; Nigro, F.; Wang, Xu

doi:10.1016/s0014-2999(00)00008-x

Cited by 43 publications

(37 citation statements)

References 32 publications

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“…Both ␣3Ϫ/Ϫ and the ␤2Ϫ/Ϫ␤4Ϫ/Ϫ animals developed severe bladder distension within 2 days after birth, and at later times they developed overflow incontinence. In the animals that survived more than 1 week, urine was often cloudy and infected with bacteria, and sometimes bladder stones completely filled the bladder (Xu et al, 1999a(Xu et al, , 1999bDe Biasi et al, 2000). Nicotine failed to induce contraction of the bladder smooth muscle in both ␣3 and ␤2␤4 null-mutant mice, but the muscle did contract in response to field stimulation or mus-carinic agonists.…”

Section: Autonomic Control Of the Lower Urinary Tractmentioning

confidence: 99%

“…The ␣3 nAChR subunit is expressed at high levels in all autonomic ganglia, including the sympathetic ganglia innervating the heart and the cardiac ganglionated plexuses (Cimino et al, 1992;Mandelzys et al, 1994;Rust et al, 1994;Poth et al, 1997). ␣3 is likely to participate in the majority of nAChR subtypes expressed by autonomic neurons (Listerud et al, 1991;Poth et al, 1997;Xu et al, 1999a;Bibevski et al, 2000) because its absence produces a severe in vivo phenotype with high perinatal mortality and autonomic dysfunction at the level of several organ systems (Xu et al, 1999a;De Biasi et al, 2000). Acutely isolated superior cervical ganglion (SCG) neurons from ␣3 null (Ϫ/Ϫ) mice express only two out of the five nAChR currents recorded from wild-type (ϩ/ϩ) neurons.…”

Section: Nachrs In the Control Of Cardiac Functionmentioning

confidence: 99%

“…3) that influence both the filling and voiding phases of micturition (deGroat and Booth, 1980;Keast et al, 1995;De Biasi et al, 2000;de Groat and Yoshimura, 2001). Preganglionic fibers traveling along the pelvic and the hypogastric nerves synapse in the pelvic plexus, which is a mixed, sympathetic/parasympathetic plexus.…”

Section: Autonomic Control Of the Lower Urinary Tractmentioning

confidence: 99%

“…In the rat and mouse, this plexus consists of the major pelvic ganglia (MPG) and a number of small accessory ganglia (Purinton et al, 1973;Keast et al, 1989). The bladder wall also contains a small number of intramural ganglia (Elbadawi and Schenk, 1966;Chesher, 1967;Ekstrom and Elmer, 1980;Elbadawi, 1982;Xu et al, 1999b;De Biasi et al, 2000) that are not easily detected and whose presence might be age dependent (Carpenter and Rubin, 1967;Alm and Elmer, 1975;Alian and Gabella, 1996).…”

Section: Autonomic Control Of the Lower Urinary Tractmentioning

confidence: 99%

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Nicotinic mechanisms in the autonomic control of organ systems

Biasi

2002

J. Neurobiol.

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Section: Autonomic Control Of the Lower Urinary Tractmentioning

confidence: 99%

Section: Nachrs In the Control Of Cardiac Functionmentioning

confidence: 99%

Section: Autonomic Control Of the Lower Urinary Tractmentioning

confidence: 99%

Section: Autonomic Control Of the Lower Urinary Tractmentioning

confidence: 99%

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Nicotinic mechanisms in the autonomic control of organ systems

Biasi

2002

J. Neurobiol.

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“…These findings in the α3 and the 2/ 4 null mice resemble the human autosomal recessive disorder known as megacystis-microcolonhypoperistalsis syndrome (MMIHS, OMIM 249210) and perhaps the related phenotype of intestinal pseudoobstruction (OMIM 243180), isolated or in association with megacystis. Further analysis of bladder function in the α3 and 2/ 4 null mice suggested that neuronal nAChRs containing α3 and 4 subunits are most prominently involved in bladder contractility, with the 2 subunits able to participate, but less significantly (De Biasi et al 2000;Xu et al 1999a;Xu et al 1999b). This is based on the finding that bladder strips from 2 null mice contract in response to nicotine, while those from α3 or 4 null mice do not, although neither the 2 or 4 single homozygotes develop megacystis, while the 2/ 4 double null and α3 single null mice have megacystis.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the human β4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4

et al. 2001

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Most neuronal nicotinic acetylcholine receptors are heteropentamers, composed of α and subunits. Mice lacking the α3 subunit and mice lacking both the 2 and 4 subunits, but not mice lacking the 2 or 4 subunits alone, have a severe phenotype characterized by megacystis, failure of bladder strips to contract in response to nicotine, widely dilated ocular pupils, growth failure, and perinatal mortality. The deficit in bladder contraction was also found in mice lacking only the 4 subunit, although they did not develop megacystis. The major bladder phenotype resembles the human autosomal recessive disorder of megacystis-microcolon-hypoperistalsis syndrome (MMIHS). Based on the similarity of the mouse and human phenotypes, we initiated mutation analyses in the α3 and 4 genes in MMIHS families. The human gene encoding the 4 subunit was fully characterized, including refinement of its mapping. Analysis of disease families and controls identified numerous genetic variants, including high-frequency polymorphisms in both CHRNA3 and CHRNB4. Although no loss-of-function mutations have been identified to date, these genes remain strong candidates for involvement in MMIHS, because various mutations might be obscured within the complex cluster of genes. Some of the markers presented here are valuable tools for analysis of the role of genetic variation in responses to nicotine and for characterization of various dysautonomic abnormalities.

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Bladder dysfunction in peripheral neuropathies

et al. 2011

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Normal bladder function depends on the complex interaction of sensory and motor pathways. Bladder dysfunction can develop as a result of several neurological conditions. It can happen in a number of ways, including diabetic cystopathy, detrusor overactivity, bladder outlet obstruction, and urge and stress urinary incontinence. Diabetic neuropathy is the most common cause of peripheral neuropathy-associated bladder dysfunction. Guillain-Barré syndrome (GBS), human immunodeficiency virus (HIV)-associated neuropathy, chronic inflammatory demyelinating polyneuropathy (CIDP), and amyloid neuropathy are other major causes. The diagnosis of bladder dysfunction should be established by the history of neurological symptoms, neurological examination, and urological evaluation. Functional evaluation of the lower urinary tract includes cystometry, sphincter electromyography, uroflowmetry, and urethral pressure profilometry. Management of urinary symptoms in patients with bladder dysfunction is usually supportive. In some cases, alpha-blocker and/or anti-muscarinic agents are needed to help improve urinary dysfunction. Intermittent self-catheterization is needed occasionally for patients with slow and/or poor recovery.

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Nicotinic acetylcholine receptors in the autonomic control of bladder function

Cited by 43 publications

References 32 publications

Nicotinic mechanisms in the autonomic control of organ systems

Nicotinic mechanisms in the autonomic control of organ systems

Characterization of the human β4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4

Bladder dysfunction in peripheral neuropathies

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