Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines

Nesil, Tanseli; Kanıt, Lütfiye; Ugur, Müzeyyen; Pöğün, Şakire

doi:10.1016/j.pbb.2015.02.009

Cited by 14 publications

(15 citation statements)

References 38 publications

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“…Mice display both somatic (e.g., shaking, paw tremors, and scratching) and affective signs of withdrawal (e.g., increased anxiety‐like behavior and anhedonia). In rats selectively bred for high vs. low nicotine preference, preference did not predict withdrawal symptoms (Nesil et al ., ), suggesting that these two nicotine traits are under independent genetic control.…”

Section: Withdrawal and Dependencementioning

confidence: 99%

“…Nine generations of the outbred Sprague-Dawley rat strain have been selected for low vs. high voluntary oral nicotine intake (i.e., two bottle-free choice) (Nesil et al, 2015). In generation (F)9 rats, the estimated heritability of high vs. low nicotine intake was 0.26 and close to 0, respectively.…”

Section: Animal Genetic Studiesmentioning

confidence: 99%

“…Evidence of genetic predisposition from selectively bred lines a. Two bottle-free choice nicotine SANesil et al (2013Nesil et al ( , 2015 b. Operant nicotine SALê et al (2006); Rezvani et al…”

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confidence: 99%

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Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco

Sharp

Chen

2018

Eur J of Neuroscience

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The single most preventable cause of disease, disability, and death in the United States is tobacco use. Decades of study show that the risk of becoming addicted to smoked cigarettes varies greatly amongst individuals and is heritable, yet environmental factors are also important contributors. In this review, we consider a wide range of methodologies and key published reports that have defined the inheritance of different stages of nicotine‐dependent smoking behavior, including preference, initiation, regular use, withdrawal and dependence as well as cessation and relapse. Major findings from both animal and human studies are discussed. Current findings converge primarily on the role of nicotinic cholinergic receptor subunits, although other neurotransmitter systems as well as nicotine metabolism enzymes are implicated. Various stages of nicotine addiction may share common genetic mechanisms, yet several lines of evidence indicate that each stage also has its own unique genetic determinants. Studies on the heritability of smoking initiation demonstrate substantial evidence for gene–environment interaction, although the precise molecular genetic mechanism(s) remains unknown. Considering the relatively few genes identified so far and the small to modest fraction of the variance in risk for a particular smoking phenotype (e.g., smoking initiation in late adolescence) attributable to these genes, a large gap remains to be filled in order to account for the heritability of key phenotypes involved in each stage of addiction to smoked tobacco. Looking forward, new research strategies involving both human and animal studies will produce the fundamental genetic insights that are the foundation for the precision medical treatment of individuals addicted to smoked tobacco.

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Section: Withdrawal and Dependencementioning

confidence: 99%

Section: Animal Genetic Studiesmentioning

confidence: 99%

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Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco

Sharp

Chen

2018

Eur J of Neuroscience

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“…Not every person who experiments with tobacco products becomes nicotine dependent, and not all smokers have identical smoking patterns. Individual differences in nicotine/tobacco addiction, including gender, have been clearly documented (Shiffman, ; Pomerleau et al, ; Perkins, ; Pomerleau, ; Shiffman and Paton, ) not only in human smokers but also in animal models of nicotine addiction (Abreu‐Villaca et al, ; Fattore et al, ; Nesil et al, ). Studies suggest that responsiveness to nicotine is influenced by both genetic and nongenetic factors (Portugal and Gould, ; Hall et al, ).…”

Section: Comparison Of the Three Animal Models Used To Study Nicotinementioning

confidence: 99%

Sex differences in nicotine preference

Pöğün

Yararbaş

Nesil

et al. 2016

J of Neuroscience Research

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Smoking is the major cause of preventable deaths worldwide, and although there is a decline in overall smoking prevalence in developed countries, the decline in women is less pronounced than in men. Women become dependent faster and experience greater difficulties in quitting. Similar trends have been observed in animal models of nicotine/tobacco addiction. Individual differences in vulnerability to drug abuse are also observed in nicotine/ tobacco addiction and point to the importance of sex differences. This Review, summarizes findings from three experimental approaches used to depict nicotine preference in animal models, intravenous and oral nicotine selfadministration and nicotine-induced conditioned place preference. Nicotine preference is considered to be reflected in the animal's motivation to administer the drug (intravenously or orally) or to prefer an environment paired with the presence of the drug (conditioned place preference). These approaches all point to the importance of sex and age of the subjects; the preference of females and adolescents appear to be more pronounced than that of males and adults, respectively. A closer look at these factors will help us understand the mechanisms that underlie nicotine addiction and develop strategies to cope. Ignoring sex differences and reaching conclusions based only on studies using male subjects has resulted in erroneous generalizations in the past. Sex differences in nicotine preference have been clearly documented, and awareness on this aspect of nicotine dependence will significantly impact our success in translational research. V C 2016 Wiley Periodicals, Inc.

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“…Na literatura, animais tratados com nicotina são, em sua maioria, utilizados em trabalhos relacionados à sensibilização da droga (FALCO et al, 2015;JACKSON et al, 2015;NESIL et al, 2015;PICCIOTTO et al, 2014) frequência arterial e o aumento da demanda de oxigênio ao miocárdio, são minimizados nos grupos com intervenção motora em esteira (CHANG, et al, 2011, MATSUDA et a., 2011, SHIMADA et al, 2013, ZHANG et al, 2012, ZHENG et al, 2011).…”

Section: A Nicotina E O Comportamento Motorunclassified

Alterações morfológicas e comportamentais em gerbilos isquêmicos induzidas pela exposição à nicotina e treino de marcha forçada contínua em esteira

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Nicotine withdrawal in selectively bred high and low nicotine preferring rat lines

Cited by 14 publications

References 38 publications

Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco

Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco

Sex differences in nicotine preference

Alterações morfológicas e comportamentais em gerbilos isquêmicos induzidas pela exposição à nicotina e treino de marcha forçada contínua em esteira

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