Nicotine transdermal systems: Pharmaceutical and clinical aspects

Panchagnula, Ramesh; Jain, Ankit; Pillai, Omathanu; Jaiswal, Jayanti

doi:10.1358/mf.2000.22.5.796649

Cited by 4 publications

(2 citation statements)

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“…Transdermal patch technology offers 1 possible route for continuous administration of dopaminergic agents. Transdermal systems have been used to deliver a variety of other medications, including sex hormones, 3 nicotine, 4 and analgesics, 5 and have been shown to lead to steady-state dose-linear plasma levels of the delivered agents. 6 The currently marketed nonergolinic dopamine agonists are relatively short-acting, and, consequently, patients take multiple oral doses throughout the day.…”

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confidence: 99%

Safety, Tolerability, and Efficacy of Continuous Transdermal Dopaminergic Stimulation with Rotigotine Patch in Early-Stage Idiopathic Parkinson Disease

Güldenpfennig¹,

Poole²,

Sommerville³

et al. 2005

Clinical Neuropharmacology

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Rotigotine is a new dopamine agonist with transdermal patch formulation for the treatment of Parkinson disease. The aim of this study was to investigate safety and efficacy of rotigotine in patients with early-stage Parkinson disease. In this open-label, dose-escalation, safety and efficacy study, 31 patients in the early stages of idiopathic Parkinson disease received rotigotine to a maximum of 18.0 mg/day. Of the 29 patients who completed the 28-day treatment phase, 24 were maintained at the maximum dose level. The drug was well tolerated, and skin reactions were mild. A statistically significant improvement in UPDRS I, II, and III scores was observed from baseline to end of treatment for the 29 subjects who completed the trial. Mean improvement (+/- standard deviation) was -0.41 +/- 0.78 on UPDRS I (P = 0.0078), -2.76 +/- 3.31 on UPDRS II (P = 0.0001), and -4.62 +/- 5.32 on UPDRS III (P < 0.0001). When results were stratified by maximum dose achieved, significant improvements were seen on all 3 subscores for patients achieving the maximum dose. These data suggest that rotigotine is a safe, well-tolerated, and effective treatment for early-stage Parkinson disease.

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confidence: 99%

Safety, Tolerability, and Efficacy of Continuous Transdermal Dopaminergic Stimulation with Rotigotine Patch in Early-Stage Idiopathic Parkinson Disease

Güldenpfennig¹,

Poole²,

Sommerville³

et al. 2005

Clinical Neuropharmacology

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“…There was no relationship between number of hair follicles and permeability values for both W and 7-OHC. The skin thickness (full) was related to the relative permeability values of W, whereas, for 7-OHC, it was not 103 .…”

Section: Sneddsmentioning

confidence: 92%

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2022

IJPSR

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Cancer refers to a group of diseases characterized by abnormal, unchecked cell growth that spreads to other body parts. Breast, liver, colorectal, kidney, stomach, lungs, and cervical cancer are the most common tumours, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percent of the cases). Surgery, chemotherapy, and other traditional medical methods have several negative side effects, including extreme inflammation and discomfort. As a result, transdermal delivery of the anticancer drug transdermal patch may be beneficial for treating multiple breast cancers via the skin. Transdermal drug penetration using various methods, such as nanocarriers, tactile penetration enhancing tools, chemical penetration enhancers, and newer innovations, such as gels, dendrimers, needle-free injection jets and so on, results in increased patient compliance, scar elimination, and economic benefit. Topical antineoplastic drug delivery is a popular option for increasing site-specific delivery, mitigating side effects, and enhancing therapeutic effects. This study aims to discuss the transdermal delivery of anticancer agents via the skin, which can open up a new frontier in cancer care using nanocarriers. INTRODUCTION:Cancer: Cancer is a broad term for a group of diseases characterized by uncontrolled cell growth that spreads throughout the body. The most common cancers are lung, liver, colorectal, prostate, thyroid, breast, and cervical cancers, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percentage of the cases). Surgery and chemotherapy, for example, have many unpleasant side effects, including severe inflammation and discomfort. New transdermal procedures and methods have been established by QUICK RESPONSE CODE

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Lifestyle and Over‐the‐Counter Drugs

Abu‐Izza

Li²,

Parr³

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter attempts to show how lifestyle drugs and over‐the counter (OTC) drugs relate to each other and the challenges that they face. It also traces the history of OTC drugs and regulations, shows how the OTC Review process works, and shows how the United States, Europe, and Japan classify OTC drugs. It briefly explains the three major criteria for Rx‐to‐OTC switch—safety, labeling, and effectiveness. The chapter also provides an overview and a generalized definition of lifestyle drugs. Four examples of lifestyle drugs are provided: hair growth drugs, smoking cessation drugs, sexual disorder drugs, and sunscreens. The selected examples cover both prescription only and OTC lifestyle drugs. The chapter ends with a look into the future for OTC and lifestyle drugs.

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Nicotine transdermal systems: Pharmaceutical and clinical aspects

Cited by 4 publications

References 0 publications

Safety, Tolerability, and Efficacy of Continuous Transdermal Dopaminergic Stimulation with Rotigotine Patch in Early-Stage Idiopathic Parkinson Disease

Safety, Tolerability, and Efficacy of Continuous Transdermal Dopaminergic Stimulation with Rotigotine Patch in Early-Stage Idiopathic Parkinson Disease

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Lifestyle and Over‐the‐Counter Drugs

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