Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3

Qin, Zhen; Wan, Jingjing; Sun, Yang; Wu, Tingyu; Wang, Peng‐Yuan; Du, Peng; Su, Ding‐Feng; Yang, Yili; Liu, Xia

doi:10.1007/s00109-016-1473-5

Cited by 43 publications

(44 citation statements)

References 46 publications

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“…Furthermore, subcutaneous or oral nicotine administration to rats treated with DNBS led to, respectively, decreased or increased colon inflammation [58,59]. Finally, while oral or subcutaneous nicotine administration attenuated inflammation caused by DSS treatment in mice [50,80], intraperitoneal nicotine injection had no effects [81,82]. Inconsistencies related to different routes of administration of CS components were also observed in human studies [83][84][85][86].…”

Section: Inhalation Studies Investigating the Effect Of Cs In Rodent mentioning

confidence: 84%

“…However, differences in immune cell recruitment [48], cytokine secretion [49][50][51], mucosal barrier [52,53] and oxidative stress were observed [54,55], although without evident tissue damage. Consistent with results of human epidemiological studies, CS had opposing effects on development of CD (negatively) and UC (positively) in several, but not all, of their respective IBD models.…”

Section: Inhalation Studies Investigating the Effect Of Cs In Rodent mentioning

confidence: 99%

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Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

Sasso¹,

Schlage²,

Phillips³

et al. 2018

Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy

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Inflammatory bowel diseases (IBDs) comprise primarily two disease manifestations, ulcerative colitis (UC) and Crohn's disease (CD), each with distinctive clinical and pathological features. Environmental and clinical factors strongly affect the development and clinical outcomes of IBDs. Among environmental factors, cigarette smoke (CS) is considered the most important risk factor for CD, while it attenuates the disease course of UC. Various animal models have been used to assess the impact of CS on intestinal pathophysiology. This chapter examines the suitability of animal inhalation/smoke exposure models for assessing the contrary effects of CS on UC and CD. It presents an updated literature review of IBD mouse models and a description of possible mechanisms relevant to relationships between IBD and smoking. In addition, it summarises various technical inhalation approaches, in the context of mouse disease models of IBD.

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Section: Inhalation Studies Investigating the Effect Of Cs In Rodent mentioning

confidence: 84%

Section: Inhalation Studies Investigating the Effect Of Cs In Rodent mentioning

confidence: 99%

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

Sasso¹,

Schlage²,

Phillips³

et al. 2018

Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy

View full text Add to dashboard Cite

show abstract

“…The DAI scoring system described previously (17,19) consists of body weight loss (zero, none; one, 1-5%; two, 5-10%; three, 10-15%; four, 15-20%), stool consistency (zero, normal; two, loose stools; four, watery diarrhea), and bloody stools (zero, normal; two, slight bleeding; four, gross bleeding). The sum of the three values constitutes the DAI.…”

Section: Disease Activity Index (Dai) Of Dss Colitismentioning

confidence: 99%

“…Histopathological colon sections were graded using the following system described previously (17): colonic mucosa thickness (zero to three), crypt abscess (zero to three), inflammatory cell infiltration (zero to three), and epithelial erosion (zero to three). The sum of the four values constitutes the HE score.…”

Section: Hematoxylin and Eosin (Hande) Staining And Scoringmentioning

confidence: 99%

“…Our previous studies found that nicotine could specifically elevate the miR-124 level in macrophages through α7nAChR and exert anti-inflammatory effects in sepsis (14). Subsequent studies found that nicotine could protect against DSS colitis (resembling UC) by increasing the miR-124 level in colonic tissues and cells (17). Intriguingly, Zhao et al also found miR-124 to be elevated in the intestinal Abbreviations: UC, ulcerative colitis; CD, Crohn's disease; IBD, inflammatory bowel disease; LNA, locked nucleic acid; DAI, disease activity index; HE, Hematoxylin-eosin; FCM, flow cytometry; CBA, cytometric bead array.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA124-IL6R Mediates the Effect of Nicotine in Inflammatory Bowel Disease by Shifting Th1/Th2 Balance Toward Th1

et al. 2020

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Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort

Gebreegziabher

Oldenburg

Shiboski

et al. 2021

ACR Open Rheumatology

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Objective. The objective of this study was to examine the association of smoking with Primary Sjögren syndrome (pSS) classification and pSS diagnostic test results. We hypothesized that past and current smokers would have lower odds of being classified as having Sjögren syndrome (SS) and lower odds of having abnormal individual SS diagnostic test results compared with nonsmokers.Methods. Participants with suspected or established pSS were enrolled into the Sjögren's International Collaborative Clinical Alliance (SICCA) registry and had oral, ocular, and rheumatologic examinations performed; blood and saliva samples collected; and labial salivary gland biopsy examinations performed; they also completed questionnaires at baseline. Logistic regression was used to determine whether smoking status was associated with pSS classification and individual pSS diagnostic test results.Results. A total of 3514 participants were enrolled in SICCA. A total of 1541 (52.9%) met classification criteria for pSS. Compared with never smokers, current smokers had reduced odds of being classified as having pSS, reduced odds of having a focus score ≥ 1 and serologic positivity for anti-SSA/anti-SSB antibodies, and lower odds of having abnormal signs or test results of dry eye disease. Compared with never smokers, past smokers did not have a statistically significant reduction in odds of being classified as having pSS and of having abnormal individual pSS diagnostic test results.Conclusion. Compared with never smokers, current smokers in the SICCA cohort had lower odds of being classified as having pSS, lower odds of exhibiting abnormal signs and test results for dry eye disease, and lower odds of having a labial salivary gland biopsy supportive of pSS classification. Such negative associations, however, do not suggest that current smoking is of any benefit with respect to pSS.

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Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3

Cited by 43 publications

References 46 publications

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

MicroRNA124-IL6R Mediates the Effect of Nicotine in Inflammatory Bowel Disease by Shifting Th1/Th2 Balance Toward Th1

Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort

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