(?)-nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats

Abstract

In this study, we sought to determine if Fischer 344 (F344) and Lewis rats showed different conditioned place preference (CPP) responses to subcutaneously administered (-)-nicotine. Lewis rats displayed a CPP response to (-)-nicotine after five pairings, whereas F344 rats showed no preference for nicotine compared to vehicle. After 10 pairings, the F344 rats showed a conditioned place aversion to (-)-nicotine, whereas the Lewis rats still displayed a significant CPP response. These results suggest that the differences in appetitiveness shown between Lewis and F344 rats to other drugs of abuse extend also to (-)-nicotine.

Intravenous nicotine conditions a place preference in rats using an unbiased design☆

“…Using rats some investigators have found that nicotine will condition an increase in time spent in the paired environment ([Ashby et al, 2002], [Calcagnetti and Schechter, 1994], [Dewey et al, 1999], [Forget et al, 2005], [Forget et al, 2006], [Fudala et al, 1985], [Fudala and Iwamoto, 1986], [Horan et al, 1997], [Horan et al, 2001], [Shoaib et al, 1994] and [Shram et al, 2006]). In contrast, other researchers have reported either avoidance (i.e., an aversion) of the nicotine-paired environment ( [Fudala and Iwamoto, 1987], [Horan et al, 1997] and [Jorenby et al, 1990]) or no place conditioning , , [Clarke and Fibiger, 1987], [Rogers et al, 2004], [Shoaib et al, 1994] and [Shram et al, 2006]). Some potential factors that might explain the inconsistent results include age and strain of the rat, pre-exposure to nicotine, and use of a biased versus unbiased procedure (see LeFoll and Goldberg (2005) for a more detailed review).…”

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

“…Lewis rats can learn to self-administer nicotine in an unlimited access procedure but not when there is limited access to nicotine, whereas Fischer 344 rats do not self-administer nicotine in either procedure [12,151]. Furthermore, Lewis rats can rapidly learn nicotine CPP when lower doses of nicotine are used, whereas Fischer 344 rats require more trials to acquire nicotine CPP at lower doses and can only learn the procedure rapidly when a high dose of nicotine is used [69,128]. In addition to these differences in the behavioral effects of nicotine, Sziraki and colleagues [166] have demonstrated that nicotineinduced increases in DA release in the nucleus accumbens is greater in Lewis rats than in Fischer 344 rats, and plasma nicotine was cleared faster in Lewis rats.…”

Effects of clomipramine on self-control choice in Lewis and Fischer 344 rats

“…In addition, Lewis rats show greater selfadministration of cocaine, morphine, codeine, and ethanol than Fisher 344 rats (Li and Lumeng, 1984;Kosten et al, 1997;Martin et al, 1999;Suzuki et al, 1988a,b). Lewis rats also show increased conditioned place preference in response to cocaine (Kosten et al, 1994) and nicotine (Horan et al, 1997) than Fischer 344 rats. Thus, the genetic, neurochemical, and behavioral differences between these two strains suggest that they might be useful models for studying impulsive behavior.…”