Nicotine potentiates the nitrergic relaxation responses of rabbit corpus cavernosum tissue via nicotinic acetylcholine receptors

Bozkurt, Nihan; Vural, Ismail Mert; Sarıoğlu, Yusuf; Pekiner, Can

doi:10.1016/j.ejphar.2006.11.053

Cited by 20 publications

(18 citation statements)

References 33 publications

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“…Initially, Furchgott called this substance endothelium-derived relaxing factor, but by the mid-1980s, he and others identified this substance as being nitric oxide (NO) 62. Today, we know that Ach released from parasympathetic terminations acts on M3 muscarinic receptors, on vascular endothelium and on nicotinic receptors located on non-adrenergic, non-cholinergic nerves;66 promoting the synthesis and release of NO, which finally leads to the relaxation of arterial and trabecular smooth muscle in the CC67 ( Figure 3b ). NO is produced as the enzymatic byproduct of molecular oxygen and L -arginine, under the control of nitric oxide synthase.…”

Section: Experimental Models Of Visceral Obesitymentioning

confidence: 99%

Erectile dysfunction and central obesity: an Italian perspective

et al. 2014

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Erectile dysfunction (ED) is a frequent complication of obesity. The aim of this review is to critically analyze the framework of obesity and ED, dissecting the connections between the two pathological entities. Current clinical evidence shows that obesity, and in particular central obesity, is associated with both arteriogenic ED and reduced testosterone (T) levels. It is conceivable that obesity-associated hypogonadism and increased cardiovascular risk might partially justify the higher prevalence of ED in overweight and obese individuals. Conversely, the psychological disturbances related to obesity do not seem to play a major role in the pathogenesis of obesity-related ED. However, both clinical and preclinical data show that the association between ED and visceral fat accumulation is independent from known obesity-associated comorbidities. Therefore, how visceral fat could impair penile microcirculation still remains unknown. This point is particularly relevant since central obesity in ED subjects categorizes individuals at high cardiovascular risk, especially in the youngest ones. The presence of ED in obese subjects might help healthcare professionals in convincing them to initiate a virtuous cycle, where the correction of sexual dysfunction will be the reward for improved lifestyle behavior. Unsatisfying sexual activity represents a meaningful, straightforward motivation for consulting healthcare professionals, who, in turn, should take advantage of the opportunity to encourage obese patients to treat, besides ED, the underlying unfavorable conditions, thus not only restoring erectile function, but also overall health.

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Section: Experimental Models Of Visceral Obesitymentioning

confidence: 99%

Erectile dysfunction and central obesity: an Italian perspective

et al. 2014

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“…ACh causes endothelium-dependent relaxation of CC, penile arteries, and circumflex and dorsal veins in vitro [32]. The presence of neuronal nicotinic ACh receptors in rabbit CC tissue and possible mechanisms underlying the nicotine's potentiation of electrical field stimulation induced relaxation were investigated by Bozkurt et al [111]. The presence of neuronal nicotinic ACh receptors in rabbit CC tissue and possible mechanisms underlying the nicotine's potentiation of electrical field stimulation induced relaxation were investigated by Bozkurt et al [111].…”

Section: Acetylcholinementioning

confidence: 99%

Erectile Dysfunction

Shamloul¹,

Bella²

2014

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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“…The presence of neuronal nicotinic ACh receptors in rabbit CC tissue and possible mechanisms underlying the nicotine's potentiation of electrical field stimulationinduced relaxation were investigated by Bozkurt et al (2007). They showed that nicotine acts on the nicotinic ACh receptors located on nitrergic nerves, thereby evoking release of NO from these nerve terminals.…”

Section: Acetylcholinementioning

confidence: 99%

“…It is important to stress that ACh also acts on nicotinic receptors (Bozkurt et al, 2007;Ozturk Fincan et al, 2010). The presence of neuronal nicotinic ACh receptors in rabbit CC tissue and possible mechanisms underlying the nicotine's potentiation of electrical field stimulationinduced relaxation were investigated by Bozkurt et al (2007).…”

Section: Acetylcholinementioning

confidence: 99%