Nicotine place preference in a biased conditioned place preference design

Brielmaier, Jennifer; McDonald, Craig G.; Smith, Robert F.

doi:10.1016/j.pbb.2007.11.005

Cited by 57 publications

(45 citation statements)

References 38 publications

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“…Though both anxiolytic and anxiogenic effects of acute nicotine administration have been documented for adult rats (e.g., File et al 1998;Irvine et al 1999), a study by Cheeta et al (2001) demonstrated anxiolytic effects in adolescents. Though we have previously demonstrated that biased nicotine CPP is not produced due to unconditioned anxiolytic effects of nicotine (Brielmaier et al 2008), we cannot rule out the possibility of conditioned anxiolysis. Thus, it is possible that prior intermittent footshock enhanced nicotine CPP acquisition due to nicotine's ability to counteract stressinduced anxiety or even by facilitating nicotine's conditioned anxiolytic effects, which along with reward may underlie nicotine's addictive properties.…”

Section: Discussionmentioning

confidence: 70%

“…Placement was counterbalanced such that half the animals started in the white side and the other half in the black side. As we previously found (Brielmaier et al 2007(Brielmaier et al , 2008, the CPP apparatus was biased, with animals spending significantly less than half of the pretest (315.18± 3.16 s) in the white side (one sample t test, [t(369)=−42.64, p<0.0001]). Time spent in the non-preferred (white) side over the pretest was scored by an observer blind to experimental conditions.…”

Section: Experiments 1: Effects Of Footshock 24 H Prior To Conditioninmentioning

confidence: 61%

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Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

2011

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Section: Discussionmentioning

confidence: 70%

Section: Experiments 1: Effects Of Footshock 24 H Prior To Conditioninmentioning

confidence: 61%

Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

2011

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“…Using a biased CPP procedure, the results of this study may also reflect differences in anxiety-related behaviors between strains (Brielmaier et al, 2008). This is because the strain differences in exploring the different compartments used in the biased CPP apparatus, shown by initial preferences, might be an indicator of strain differences in anxiety-like behavior (Crawley, 1985).…”

Section: Discussionmentioning

confidence: 91%

Strain-dependent performance in nicotine-induced conditioned place preference.

Kutlu

Ortega

Gould

2015

Behavioral Neuroscience

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Nicotine addiction is most likely a result of a combination of factors including the rewarding effects of the drug; these effects, however, might be influenced by genetic background. Using a conditioned place preference (CPP) paradigm and 8 inbred mouse strains, we conducted an initial examination of the role of genetic background in the rewarding effects of nicotine. Following habituation and initial place preference test, inbred strains (A/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1J, DBA/2J, and 129/SvEv) were trained and tested in CPP for nicotine (0.35 mg/kg). Although several strains (C57BL/6J, CBA/J, and 129/SvEv) showed nicotine-induced CPP, 1 strain (DBA/1J) showed conditioned place aversion (CPA), and other strains (A/J, BALB/cByJ, C3H/HeJ, and DBA/2J) did not show CPP. Overall, these results indicate that nicotine’s rewarding effects tested in CPP are differentially affected by the genetic background, and this trait has a relatively high heritability (42%–57%). This initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward.

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“…In humans, nicotine results in euphoria, increased energy and arousal, and suppressed anxiety Pomerleau 1985, 1992;Stolerman and Jarvis 1995;Benowitz 1996). Accordingly, in animals, acute injections of nicotine leads to CPP (Fudala et al 1985;Risinger and Oakes 1995;Vastola et al 2002;Grabus et al 2006;Brielmaier et al 2008;Kutlu et al 2015a). Similarly, there is also evidence showing that smokers learn to associate nicotine's effects with specific contexts and cues (Dols et al 2000(Dols et al , 2002Thewissen et al 2005), suggesting humans and animals learn to associate nicotine's rewarding effects with specific contextual cues.…”

Section: Nicotinementioning

confidence: 99%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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It has long been hypothesized that conditioning mechanisms play major roles in addiction. Specifically, the associations between rewarding properties of drugs of abuse and the drug context can contribute to future use and facilitate the transition from initial drug use into drug dependency. On the other hand, the self-medication hypothesis of drug abuse suggests that negative consequences of drug withdrawal result in relapse to drug use as an attempt to alleviate the negative symptoms. In this review, we explored these hypotheses and the involvement of the hippocampus in the development and maintenance of addiction to widely abused drugs such as cocaine, amphetamine, nicotine, alcohol, opiates, and cannabis. Studies suggest that initial exposure to stimulants (i.e., cocaine, nicotine, and amphetamine) and alcohol may enhance hippocampal function and, therefore, the formation of augmented drug-context associations that contribute to the development of addiction. In line with the self-medication hypothesis, withdrawal from stimulants, ethanol, and cannabis results in hippocampus-dependent learning and memory deficits, which suggest that an attempt to alleviate these deficits may contribute to relapse to drug use and maintenance of addiction. Interestingly, opiate withdrawal leads to enhancement of hippocampus-dependent learning and memory. Given that a conditioned aversion to drug context develops during opiate withdrawal, the cognitive enhancement in this case may result in the formation of an augmented association between withdrawalinduced aversion and withdrawal context. Therefore, individuals with opiate addiction may return to opiate use to avoid aversive symptoms triggered by the withdrawal context. Overall, the systematic examination of the role of the hippocampus in drug addiction may help to formulate a better understanding of addiction and underlying neural substrates.Addiction is a major worldwide health problem that results in maladaptive behavioral changes, some that can last a lifetime. This behavioral plasticity, often times maladaptive, must be associated changes in neural plasticity. In fact, it has been noted multiple times that there is a high degree of overlap between the neurobiology of learning and memory and the neurobiology of addiction

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Nicotine place preference in a biased conditioned place preference design

Cited by 57 publications

References 38 publications

Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors

Strain-dependent performance in nicotine-induced conditioned place preference.

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

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