Nicotine Nasal Spray as an Adjuvant Analgesic for Third Molar Surgery

Yagoubian, Benjamin; Akkara, Joseph A.; Afzali, Payam; Alfi, David M.; Olson, Luke C.; Conell-Price, Jessamyn; Yeh, Janet; Eisig, Sidney B.; Flood, Pamela

doi:10.1016/j.joms.2010.07.025

Cited by 18 publications

(6 citation statements)

References 13 publications

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“…The antinociceptive and antiallodynic properties of nicotine have been demonstrated in numerous animal and human studies (Flood and Damaj, 2014), including neuropathic pain in humans (Rowbotham et al, 2009;Richardson et al, 2012). Randomized, double-blind, placebo-controlled trials have reported that intranasal or transdermal administration of nicotine preoperatively or postoperatively results in significantly decreased pain scores and lower morphine consumption, respectively (Flood and Daniel, 2004;Habib et al, 2008;Yagoubian et al, 2011). Similarly, laboratory animal studies have revealed that nicotine acts as an antinociceptive drug in a variety of acute and chronic pain models in rodents (Alsharari et al, 2012(Alsharari et al, , 2015.…”

Section: Nicotine Prevents and Reverses Murine Cipnmentioning

confidence: 99%

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN

Kyte

Toma

Bağdaş

et al. 2017

J Pharmacol Exp Ther

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Chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect during and/or after cancer chemotherapy. Paclitaxel, a taxane commonly used to treat breast, lung, and ovarian cancers, causes CIPN in 59-78% of cancer patients. Novel interventions are needed due to the current lack of effective CIPN treatments. Our studies were designed to investigate whether nicotine can prevent and/or reverse paclitaxel-induced peripheral neuropathy in a mouse model of CIPN, while ensuring that nicotine will not stimulate lung tumor cell proliferation or interfere with the antitumor properties of paclitaxel. Male C57BL/6J mice received paclitaxel every other day for a total of four injections (8 mg/kg, i.p.). Acute (0.3-0.9 mg/kg, i.p.) and chronic (24 mg/kg per day, s.c.) administration of nicotine respectively reversed and prevented paclitaxel-induced mechanical allodynia. Blockade of the antinociceptive effect of nicotine with mecamylamine and methyllycaconitine suggests that the reversal of paclitaxel-induced mechanical allodynia is primarily mediated by the 7 nicotinic acetylcholine receptor subtype. Chronic nicotine treatment also prevented paclitaxel-induced intraepidermal nerve fiber loss. Notably, nicotine neither promoted proliferation of A549 and H460 non-small cell lung cancer cells nor interfered with paclitaxel-induced antitumor effects, including apoptosis. Most importantly, chronic nicotine administration did not enhance Lewis lung carcinoma tumor growth in C57BL/6J mice. These data suggest that the nicotinic acetylcholine receptor-mediated pathways may be promising drug targets for the prevention and treatment of CIPN.

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Section: Nicotine Prevents and Reverses Murine Cipnmentioning

confidence: 99%

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN

Kyte

Toma

Bağdaş

et al. 2017

J Pharmacol Exp Ther

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“…Beyond the activation of nAChRs and possible dopamine re-enforced pleasure in alcohol–nicotine co-use another contributory factor could be the analgesic (or antinociceptive) effect of such a combination. Nicotine in itself appears to be effective as a reducer of pain and inflammation in many situations (Decker et al 2001; Yagoubian et al 2011; Yoshikawa et al 2006). Nicotine’s analgesic ability was first demonstrated before the identification of nAChRs (Davis et al 1932), but the activation of the nAChRs has long been suggested as a key component in mediation of analgesic effects of nicotine and other nicotinic agonists (e.g., epibatidine, see below: Damaj et al 1999; Khan et al 1998; Simons et al 2005; Vincler 2005).…”

Section: Contributory Factors To Alcohol and Tobacco Co-morbiditymentioning

confidence: 99%

Positive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review

2011

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Nicotine and alcohol are two of the most commonly abused legal substances. Heavy use of one drug can often lead to, or is predictive of, heavy use of the other drug in adolescents and adults. Heavy drinking and smoking alone are of significant health hazard. The combination of the two, however, can result in synergistic adverse effects particularly in incidences of various cancers (e.g., esophagus). Although detrimental consequences of smoking are well established, nicotine by itself might possess positive and even therapeutic potential. Similarly, alcohol at low or moderated doses may confer beneficial health effects. These opposing findings have generated considerable interest in how these drugs act. Here we will briefly review the negative impact of drinking–smoking co-morbidity followed by factors that appear to contribute to the high rate of co-use of alcohol and nicotine. Our main focus will be on what research is telling us about the central actions and interactions of these drugs, and what has been elucidated about the mechanisms of their positive and negative effects. We will conclude by making suggestions for future research in this area.

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“…These results coincide with the study by Ali and Sakr who reported that pre-emptive application of transdermal 7 mg nicotine patch 2 h before surgery, had an analgesic effect in patients undergoing lumber disk surgery reducing the intra-operative fentanyl requirements and postoperative cumulative morphine consumptions and led to improved pain control [34]. Yagoubian et al, documented that preoperatively administered nicotine nasal spray (3 mg) was associated with a highly significant decrease in pain reported during the 5 days after third molar surgery [35].…”

Section: Discussionmentioning

confidence: 99%

Comparative study between transdermal nicotine and melatonin patches on postoperative pain relief after laparoscopic cholecystectomy, a double-blind, placebo-controlled trial

Esmat

Kassim²

2016

Egyptian Journal of Anaesthesia

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Background: This study evaluated the efficacy of transdermal nicotine (TDN) delivery system (15 mg/16 h) or transdermal melatonin (TDM) delivery system (7 mg) 2 h preoperatively for acute postoperative pain after laparoscopic cholecystectomy compared to placebo group (C). Methods: Sixty female non-smoker patients, aged 18-50 years and ASA I and II undergoing elective laparoscopic cholecystectomy under general anesthesia were included in this randomized controlled double-blind study. Patients were randomly divided into 3 groups 20 each, and C group patients received transdermal placebo patch, TDN group (15 mg/16 h) and TDM group (7 mg/8 h). Assessment of postoperative pain, sedation, hemodynamic variables such as HR and MAP, postoperative monitoring of arterial SpO 2 and side effects (e.g. nausea, vomiting, pruritus, respiratory depression and hemodynamic instability) were done 30 min, 1, 2, 6 and 12 h postoperatively. Postoperative Patient's and Surgeons' satisfaction, Intraoperative bleeding and plasma cortisol (lg/dl) 2 h postoperatively were also assessed. Results: There was a significant reduction in the VAS score, total pethidine requirements (mg) and significantly higher patient's satisfaction in TDN and TDM groups when compared with the C group postoperatively. The sedation score and surgeons' satisfaction were significantly higher associated with a significant decrease in MAP and Intraoperative bleeding in TDM group compared to C and TDN groups postoperatively. Significant nausea and vomiting in TDN group and significant sedation in TDM group were recorded. Conclusion: The use of preoperative TDN (15 mg/16 h) or TDM (7 mg/8 h) was an effective and a safe adjuvant for acute pain after surgery.

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Nicotine Nasal Spray as an Adjuvant Analgesic for Third Molar Surgery

Cited by 18 publications

References 13 publications

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN

Positive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review

Comparative study between transdermal nicotine and melatonin patches on postoperative pain relief after laparoscopic cholecystectomy, a double-blind, placebo-controlled trial

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