Nicotine Nasal Inhalation, Atrial Fibrillation and Seizures

Nunes, José Pedro L.; Barbosa, Emília Maria Wanderley de Gusmão; Lopes, Luís; Alves, Carlos; Gonçalves, Francisco Rocha

doi:10.1159/000047389

Cited by 12 publications

(5 citation statements)

References 2 publications

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“…9,12 Nevertheless abuse with nasal snuff or nicotine-containing therapeutic sprays may lead to life-threatening arrhythmias, rst because of the doses administered, and second because of the extremely high absorption rate. 9,25 Effects of dry snuff on the nose There are very few clinical reports on the problem, because of the limited spread of this form of tobacco abuse today. Probably the physicians from earlier times were more familiar with the snuff-induced changes in the nose.…”

Section: Cardiovascular Aspectsmentioning

confidence: 99%

Nasal snuff: historical review and health related aspects

Sapundzhiev

Werner

2003

J. Laryngol. Otol.

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With cigarette smoking declining in the modern world, the tobacco industry has to look for other products that can keep the old customers and attract new ones. Different forms of smokeless tobacco are currently massively promoted and are gaining in importance. Dry nasal snuff--the oldest known form of tobacco in Europe--is one of them. The health risks associated with it are different to those attributed to smoking and oral wet snuff. The nicotine contained leads to dependency. Its resorption rate is similar to that of smoking, so it could be seen as an adequate substitutional therapy. The risk for cardiovascular diseases is lower, compared to that for smokers. Chronic abuse leads to morphological and functional changes in the nasal mucosa. Although it contains substances that are potentially carcinogenic, at present, there is no firm evidence, relating the use of nasal snuff to a higher incidence of head and neck or other malignancies.

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Section: Cardiovascular Aspectsmentioning

confidence: 99%

Nasal snuff: historical review and health related aspects

Sapundzhiev

Werner

2003

J. Laryngol. Otol.

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“…These studies indicate that tobacco smoking may accelerate atrial remodeling, contributing to the development of AF. Although several case reports have reported the onset of AF following ingestion of nicotine [27,28], the results of population-based studies examining the association between smoking and AF are conflicting. In several cohort studies, the effect of smoking on incidence of AF was not independent [29][30][31][32][33], while recent large-scale cohort studies with longer-term follow-up periods have demonstrated that smoking is independently associated with the development of AF [34,35].…”

Section: Introductionmentioning

confidence: 99%

Association between smoking habits and the first-time appearance of atrial fibrillation in Japanese patients: Evidence from the Shinken Database

Suzuki

Otsuka

Sagara

et al. 2015

Journal of Cardiology

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Smoking was independently associated with the first-appearance of AF in patients in sinus rhythm, especially when the patients continued their smoking habit. However, in patients who continued smoking, difference by total tobacco consumption was not observed, suggesting the significance of cessation of smoking for preventing AF. Our data are limited because of a single hospital-based nature and a relatively short observation period.

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“…The studies indicate that tobacco smoking may accelerate atrial remodeling, contributing to the development of AF. Although several case reports have reported the onset of AF following ingestion of nicotine, 27, 28 the results of population-based studies examining the association between smoking and AF are conflicting. In several cohort studies, the effect of smoking on the incidence of AF was not independent, 29-33 but recent large-scale cohort studies with longer-term follow-up periods have demonstrated that smoking is independently associated with the development of AF.…”

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confidence: 99%

Effects of Smoking Habit on the Prevalence of Atrial Fibrillation in Japanese Patients With Special Reference to Sex Differences

Suzuki

Sagara

Otsuka

et al. 2013

Circ J

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Background: Tobacco smoking is a well-known risk factor for cardiovascular disease, but controversial results have been reported regarding its relationship with atrial fibrillation (AF). Moreover, no study on the relationship between smoking and AF has yet been undertaken in a Japanese context. Methods and Results:We used data from the Shinken Database 2004-2011 (men/women, n=10,714/6,803, respectively), which included all new patients attending the Cardiovascular Institute between June 2004 and March 2012. AF was diagnosed in 1,698 and 598 men and women, respectively. In men, smokers were more prevalent in the AF than in the non-AF group (54.5% vs. 44.7%), whereas in women the prevalence of smokers was similar between AF and non-AF groups (14.4% vs. 15.4%). This discrepancy between the sexes seems to derive from a characteristic distribution pattern of smoking habit in women. After adjustment for various cofactors, smoking was independently associated with AF (odds ratio 1.54; 95% confidence interval 1.35-1.75; P<0.001) without a significant interaction between sex categories (P=0.195). Conclusions:Smoking was independently associated with AF without a significant interaction between sex categories among Japanese patients visiting a cardiovascular hospital. Further studies using a prospective cohort design are required to confirm a causal link between smoking and AF in Japanese patients. (Circ J 2013; 77: 2948 -2953

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Nicotine Nasal Inhalation, Atrial Fibrillation and Seizures

Cited by 12 publications

References 2 publications

Nasal snuff: historical review and health related aspects

Nasal snuff: historical review and health related aspects

Association between smoking habits and the first-time appearance of atrial fibrillation in Japanese patients: Evidence from the Shinken Database

Effects of Smoking Habit on the Prevalence of Atrial Fibrillation in Japanese Patients With Special Reference to Sex Differences

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