Nicotine-mediated therapy for Parkinson’s disease in transgenic Caenorhabditis elegans model
Inam Ullah,
Longhe Zhao,
Shahab Uddin
et al.
Abstract:Parkinson’s disease resultant in the degeneration of Dopaminergic neurons and accumulation of α-synuclein in the substantia nigra pars compacta. The synthetic therapeutics for Parkinson’s disease have moderate symptomatic benefits but cannot prevent or delay disease progression. In this study, nicotine was employed by using transgenic Caenorhabditis elegans Parkinson’s disease models to minimize the Parkinson’s disease symptoms. The results showed that the nicotine at 100, 150, and 200 μM doses reduced degener… Show more
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