Nicotine injected into the antennal lobes induces a rapid modulation of sucrose threshold and improves short-term memory in the honeybee Apis mellifera

Thany, Steeve Hervé; Gauthier, M.

doi:10.1016/j.brainres.2005.01.056

Cited by 48 publications

(35 citation statements)

References 15 publications

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“…Injections of 100 and 1000 µM nicotine increased sucrose sensitivity within minutes after administration (Thany and Gauthier, 2005). Increased sucrose sensitivity may counterbalance possible effects of bitterness on sweetness perception, and may have caused the ingestion of fairly high nicotine concentrations in our study.…”

Section: Feeding Response To Nectar Nicotinementioning

confidence: 81%

“…Nicotine, when injected in low concentrations (10 µM) into the antennal lobes of honeybees, did not interfere with olfactory learning, and even improved short-term memory (Thany and Gauthier, 2005).…”

Section: Feeding Response To Nectar Nicotinementioning

confidence: 96%

“…Nicotine is a naturally occurring alkaloid which is widely distributed in the plant kingdom, but best known from the family Solanaceae, which includes many agricultural crops and 33Ttobacco33T (Leete, 1983;Siegmund et al, 1999). Nicotine is highly toxic to most herbivores through its action on acetylcholine receptors, thus affecting various biological functions (Kleinsasser et al, 2005;Thany and Gauthier, 2005;Yildiz, 2004). Pollinators may encounter nicotine in both nectar and pollen (Detzel and Wink, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Honeybees and nectar nicotine: Deterrence and reduced survival versus potential health benefits

Köhler

Pirk

Nicolson

2012

Journal of Insect Physiology

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Secondary metabolites produced by plants for herbivore defence are often found in floral nectar, but their effect on the foraging behaviour and physiological performance of pollinators is largely unknown. Nicotine is highly toxic to most herbivores, and nicotine-based insecticides may contribute to current pollinator declines. We examined the effects of nectar nicotine on honeybee foraging choices and worker longevity. Free-flying honeybee (Apis mellifera scutellata) workers from six colonies were given a choice between multiple nicotine concentrations (0-1000 µM) in artificial nectar (0.15-0.63 M sucrose). The dose-dependent deterrent effect of nicotine was stronger in lower sugar concentrations, but even the highest nicotine concentrations did not completely repel honeybees, i.e. bees did not stop feeding on these diets. Nicotine in nectar acts as a partial repellent, which may keep pollinators moving between plants and enhance crosspollination. In the second part of the study, newly emerged workers from 12 colonies were caged and fed one of four nicotine concentrations (0-300 µM) in 0.63 M sucrose for 21 days. Moderate (≤30 µM) nicotine concentrations had no significant detrimental effect, but high nicotine concentrations reduced the survival of caged workers and their nectar storage in the honey comb.In contrast, worker groups that survived poorly on sugar-only diets demonstrated increased survival on all nicotine diets. In the absence of alternative nectar sources, honeybees tolerate naturally occurring nectar nicotine concentrations; and low concentrations can even be beneficial to honeybees. However, high nicotine concentrations may have a detrimental effect on colony fitness.

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Section: Feeding Response To Nectar Nicotinementioning

confidence: 81%

Section: Feeding Response To Nectar Nicotinementioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Honeybees and nectar nicotine: Deterrence and reduced survival versus potential health benefits

Köhler

Pirk

Nicolson

2012

Journal of Insect Physiology

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“…a 100-fold lower pheromone dose is necessary to elicit a response in neurons after intoxication compared with solvent (DMSO)-treated males. This result can be compared with findings in the honeybee, showing that nicotine, a potent ligand of nAChRs, at doses of 10 25 to 10 26 M can increase the sensitivity of the gustatory system to sugar, and can improve olfactory memory, even though the underlying neural mechanisms have not been investigated [42]. The differential effects of clothianidin on the central nervous pheromone responses may be explained by the involvement of distinct nAChR subtypes with different affinities to this ligand.…”

Section: Discussionmentioning

confidence: 93%

“…Different subunit combinations generate nAChRs with different pharmacological properties [43]. Certain nicotinic receptor subunits have in addition been shown to be differentially expressed in different parts of the honeybee brain, including areas treating olfactory information such as the ALs [42,[44][45][46]. We hypothesize that different nAChR types with different affinities to clothianidin are expressed in different neuron types within the AL network, which could cause the opposing effects of different doses.…”

Section: Discussionmentioning

confidence: 99%

Low doses of a neonicotinoid insecticide modify pheromone response thresholds of central but not peripheral olfactory neurons in a pest insect

et al. 2016

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Insect pest management relies mainly on neurotoxic insecticides, including neonicotinoids, leaving residues in the environment. There is now evidence that low doses of insecticides can have positive effects on pest insects by enhancing various life traits. Because pest insects often rely on sex pheromones for reproduction, and olfactory synaptic transmission is cholinergic, neonicotinoid residues could modify chemical communication. We recently showed that treatments with different sublethal doses of clothianidin could either enhance or decrease behavioural sex pheromone responses in the male moth, Agrotis ipsilon. We investigated now effects of the behaviourally active clothianidin doses on the sensitivity of the peripheral and central olfactory system. We show with extracellular recordings that both tested clothianidin doses do not influence pheromone responses in olfactory receptor neurons. Similarly, in vivo optical imaging does not reveal any changes in glomerular response intensities to the sex pheromone after clothianidin treatments. The sensitivity of intracellularly recorded antennal lobe output neurons, however, is upregulated by a lethal dose 20 times and downregulated by a dose 10 times lower than the lethal dose 0. This correlates with the changes of behavioural responses after clothianidin treatment and suggests the antennal lobe as neural substrate involved in clothianidin-induced behavioural changes.

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Analysis of aflatoxins, caffeine, nicotine and heavy metals in Palestinian multifloral honey from different geographic regions

Swaileh

Abdulkhaliq

2013

J Sci Food Agric

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Nicotine injected into the antennal lobes induces a rapid modulation of sucrose threshold and improves short-term memory in the honeybee Apis mellifera

Cited by 48 publications

References 15 publications

Honeybees and nectar nicotine: Deterrence and reduced survival versus potential health benefits

Honeybees and nectar nicotine: Deterrence and reduced survival versus potential health benefits

Low doses of a neonicotinoid insecticide modify pheromone response thresholds of central but not peripheral olfactory neurons in a pest insect

Analysis of aflatoxins, caffeine, nicotine and heavy metals in Palestinian multifloral honey from different geographic regions

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