Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons

Ehlinger, Daniel G.; Burke, Julian C.; McDonald, Craig G.; Smith, Robert F.; Bergstrom, Hadley C.

doi:10.1016/j.neuroscience.2017.05.036

Cited by 12 publications

(7 citation statements)

References 65 publications

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“…In addition, we did not find differences between aDLS and pDMS in terms of dendritic volume or area. DLS MSN dendritic arbors were recently reported to be larger and more complex compared to DMS dendritic arbors [ 85 ], but this study did not assess exactly the differences between pDMS and aDLS neurons and was conducted in rats. It is important to note that in our study we focused on the morphological characteristic of the dendrites, but not on the neuronal structure.…”

Section: Discussionmentioning

confidence: 99%

Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum

et al. 2018

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Derivatives from the Cannabis plant are the most commonly abused illegal substances in the world. The main psychoactive component found in the plant, Δ-9-tetrahydrocannabinol (THC), exerts its effects through the endocannabinoid system. Manipulations of this system affect some types of learning that seem to be dependent on dorsal striatum synaptic plasticity. Dendritic spines exhibit important synaptic functional attributes and a potential for plasticity, which is thought to mediate long-lasting changes in behaviour. To study the possible structural plasticity changes that prolonged THC administration might exert in the dorsal striatum, adult, male C57BL6/J mice were intraperitoneally injected with THC (10mg/kg) or vehicle for 15 days followed by a 7-day drug-free period. Using single cell intracellular injections of Lucifer Yellow, confocal microscopy, and 3D reconstruction of labelled neurons, we studied dendritic spine density and spine size in medium spiny neurons (MSNs) of the anterior dorsolateral striatum (aDLS) and posterior dorsomedial striatum (pDMS). We found that the THC treatment increased dendritic spine density in the distal part of the dendrites of MSNs in the pDMS, but no changes were found in the rest of the parameters analysed in either region studied. We also observed that dendritic spines of MSNs of pDMS presented lower volume and surface area values than MSNs of the aDLS. These results seem to indicate that THC could induce structural plasticity alterations in the circuits involving pDMS MSNs.

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Section: Discussionmentioning

confidence: 99%

Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum

et al. 2018

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“…These were obtained by querying NeuroMorpho.Org's "Browse by Random" tool, once for 50 random cells and once for 10 random cells, and filtering for those meeting the stated criteria. The randomly selected morphologies as identified by their NeuroMorpho.Org name are: 9CL-IVxAnk2-IR_ddaC (Nanda et al, 2018), 29-1-8 (Martinez-Canabal et al, 2013, 64-8-L-B-JB (Ehlinger et al, 2017), 243-3-39-AW (Nguyen et al, 2020), 2017-25-04-slice-2-cell-2-rotated (Scala et al, 2019), 070601-exp1-zB (Groh et al, 2010), 160524_7_4 (Kunst et al, 2019), 15892037 (Takagi et al, 2017), AE5_EEA_Outer-thirds_DG-Mol_sec1-cel4-aev5me (de Oliveira et al, 2020), AM61-2-1 and AM81-2-3 (Trevelyan et al, 2006)…”

Section: Boundary Identificationmentioning

confidence: 99%

Efficient simulation of 3D reaction-diffusion in models of neurons and networks

McDougal

Conte

Eggleston

et al. 2022

Preprint

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Neuronal activity is the result of both the electrophysiology and chemophysiology. A neuron can be well represented for the purposes of electrophysiological simulation as a tree composed of connected cylinders. This representation is also apt for 1D simulations of their chemophysiology, provided the spatial scale is larger than the diameter of the cylinders and there is radial symmetry. Higher dimensional simulation is necessary to accurately capture the dynamics when these criteria are not met, such as with wave curvature, spines, or diffusion near the soma. We have developed a solution to enable efficient finite volume method simulation of reaction-diffusion kinetics in intracellular 3D regions in neuron and network models and provide an implementation within the NEURON simulator. An accelerated version of the CTNG 3D reconstruction algorithm transforms morphologies suitable for ion-channel based simulations into consistent 3D voxelized regions. Kinetics are then solved using a parallel algorithm based on Douglas-Gunn that handles the irregular 3D geometry of a neuron; these kinetics are coupled to NEURON's 1D mechanisms for ion channels, synapses, etc. The 3D domain may cover the entire cell or selected regions of interest. Simulations with dendritic spines and of the soma reveal details of dynamics that would be missed in a pure 1D simulation. We describe and validate the methods and discuss their performance.

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“…Repeated nicotine exposure increases extracellular glutamate concentrations in rat CPu and NAc as determined by real-time glutamate biosensing and microdialysis [13,27]. Chronic administration of nicotine increases dopamine release in the striatum [27,28]. Systemic repeated exposure to nicotine dose-dependently increases dopamine levels in the CPu and NAc [29], and that local infusion of nicotine increases glutamate release in the striatum [6,30].…”

Section: The Striatum Potentiates Glutamate Release After Nicotinementioning

confidence: 99%

“…For example, chronic treatment with the nicotine analog, choline, increased the expression and release of BDNF from cultured cortical neurons [83]. Stimulation of α7 nAChRs in the SH-SY5Y cell line increased BDNF synthesis and secretion [82,83], whereas treatment with MLA, an α7 nAChR antagonist, reduced the nicotine-induced BDNF over-expression in this cell line [28]. These findings suggest that nicotine-induced α7 nAChR stimulation is responsible for the expression of BDNF, which facilitates anterograde BDNF release to the striatum from cortices.…”

Section: Bdnf Differently Regulates Behavior According To the Condmentioning

confidence: 99%

Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration

Kim

Yang

Ryu

et al. 2019

IJMS

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Nicotine causes tobacco dependence, which may result in fatal respiratory diseases. The striatum is a key structure of forebrain basal nuclei associated with nicotine dependence. In the striatum, glutamate release is increased when α7 nicotinic acetylcholine receptors expressed in the glutamatergic terminals are exposed to nicotine, and over-stimulates glutamate receptors in gamma amino-butyric acid (GABA)ergic neurons. These receptor over-stimulations in turn potentiate GABAergic outputs to forebrain basal nuclei and contribute to the increase in psychomotor behaviors associated with nicotine dependence. In parallel with glutamate increases, nicotine exposure elevates brain-derived neurotrophic factor (BDNF) release through anterograde and retrograde targeting of the synapses of glutamatergic terminals and GABAergic neurons. This article reviews nicotine-exposure induced elevations of glutamatergic neurotransmission, the bidirectional targeting of BDNF in the striatum, and the potential regulatory role played by BDNF in behavioral responses to nicotine exposure.

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Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons

Cited by 12 publications

References 65 publications

Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum

Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum

Efficient simulation of 3D reaction-diffusion in models of neurons and networks

Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration

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