Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects

Zhang, Wenji; Lin, Hui Ching; Zou, Man; Yuan, Qinghua; Huang, Zhenrui; Pan, Xiaoying; Zhang, Wenjuan

doi:10.3389/fimmu.2022.826889

Cited by 49 publications

(44 citation statements)

References 164 publications

(164 reference statements)

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“…Positive associations were expected since smoking-related oxidative stress is associated with inflammation. Smoking has, however, both pro- and anti-inflammatory effects [ 24 , 25 , 26 ]. Smoking was negatively associated with QA, which has neurotoxic effects [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease

et al. 2023

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Background: Changes in tryptophan metabolism through the kynurenine pathway (KP) canis observed in several disorders and coupled with pathophysiological deviations. Methods: This study retrospectively compared the KP in serum in healthy subjects (108) with subjects with obesity (141), depression (49), and chronic obstructive pulmonary disease (COPD) (22) participating in four clinical studies and explored predictors of the changes in the KP metabolites. Results: Compared with the healthy group, the KP was upregulated in the disease groups with high kynurenine, quinolinic acid (QA), kynurenine/tryptophan-ratio and QA/xanthurenic acid-ratio and low kynurenic acid/QA-ratio. Tryptophan and xanthurenic acid were upregulated in the depressed group compared with the groups with obesity and COPD. The covariates BMI, smoking, diabetes, and C-reactive protein explained the significant differences between the healthy group and the group with obesity but not between the healthy group and the groups with depression and COPD, indicating that different pathophysiological conditions result in the same changes in the KP. Conclusions: The KP was significantly upregulated in the disease groups compared with the healthy group, and there were significant differences between the disease groups. Different pathophysiological abnormalities seemed to result in the same deviations in the KP.

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Section: Discussionmentioning

confidence: 99%

The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease

et al. 2023

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“…There are several possible reasons that may explain these causalities. (1) Tobacco smoking increases the levels of pro-inflammatory cytokines such as tumor necrosis factor alpha and interleukin 6, which may result in a higher risk of infectious diseases [24]. (2) Potentially toxic substances in tobacco smoking can damage the vascular endothelial cells, thus increasing susceptibility to many infectious diseases [5].…”

Section: Discussionmentioning

confidence: 99%

Causal Associations Between Tobacco, Alcohol Use and Risk of Infectious Diseases: A Mendelian Randomization Study

et al. 2023

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Introduction:The causal effects of smoking and alcohol use on the risk of infectious diseases are unclear, and it is hard investigate them in an observational study due to the potential confounding factors. The aim of this study was to use Mendelian randomization (MR) techniques to assess the causalities between smoking, alcohol use and risk of infectious diseases. Methods: Univariable and multivariable MR analyses were performed using genome-wide association data for the age of initiation of regular smoking (AgeSmk, N = 341,427), smoking initiation (SmkInit, N = 1,232,091), cigarettes per day (CigDay, N = 337,334), lifetime Hongxiang Zhu and Xiaohui Zhan contributed equally.

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“…Importantly, leukocyte migration, activation, and retention in in amed ocular tissue are mediated by chemokines and their receptors, which may represent potential therapeutic targets. [19]. calprotectin is proteins that have been extensively researched in in ammatory disease [20].…”

Section: Discussionmentioning

confidence: 99%

Calprotectin as a non-invasive biomarker for Acute Noninfectious Granulomatous Anterior Uveitis in Egyptian Patients

Nage

Esmail

2022

Preprint

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Purpose To study the relation between serum calprotectin level and acute noninfectious anterior uveitis in Egyptian patients. Methods An observational prospective study carried out at Menoufia University Hospital during the period from march 2021 till June 2022, after informed consent from all studied patients. This study included 20 eyes of patients with Acute Anterior Uveitis (AAU) and 20 eyes healthy individuals matched sex and age as the control group. Full history taking, ophthalmological examination and serum calprotectin levels were performed for both patients and controls. Results The majority of AAU patients' eyes (55%) had a moderate grade, followed by a faint grade (30%) and a pronounced grade (15%). Serum calprotectin levels were substantially higher in patients with acute anterior uveitis than in healthy eyes (61.45 ± 7.89 vs. 32.50 ± 11.64; 95% CI: 22.58–35.32; P < 0.001). In comparison to negative previous uveitis and mild to moderate anterior uveitis, serum calprotectin levels were substantially higher with positive previous uveitis (64.75 ± 4.65) and notable grade (67.00 ± 2.65). The serum calprotectin cutoff point for diagnosing AAU was 58.0, with sensitivity of 95% and specificity of 43%. Serum calprotectin had a cutoff value in the prognosis of AAU of 63.0, with a sensitivity of 91.7% and a specificity of 37.5%. Conclusion Serum calprotectin levels was significantly higher with positive previous uveitis and marked grade indicating a possible role of calprotectin in the pathogenesis of noninfectious AAU. Finally, we discovered serum calprotectin as a possible biomarker for predicting patients' mortality risk and the likelihood of developing anterior uveitis, whose prompt monitoring may enhance the prognosis of anterior uveitis.

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Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects

Cited by 49 publications

References 164 publications

The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease

The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease

Causal Associations Between Tobacco, Alcohol Use and Risk of Infectious Diseases: A Mendelian Randomization Study

Calprotectin as a non-invasive biomarker for Acute Noninfectious Granulomatous Anterior Uveitis in Egyptian Patients

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