Nicotine in adolescence freezes dopamine circuits in an immature state
Lauren M. Reynolds,
Aylin Gulmez,
Sophie L. Fayad
et al.
Abstract:Nicotine use during adolescence is largely associated with negative long-term outcomes, including addiction to nicotine in adulthood. How nicotine acts on developing neurocircuitry in adolescence remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescence was sufficient for adult mice to show a marked vulnerability to nicotine. Brain-wide activity mapping showed that these mice had an enhanced response to an acute ni… Show more
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