Abstract:Strong epidemiological evidence and studies in models of Parkinson’s disease (PD) suggest that nicotine may be therapeutically beneficial in PD patients. However, a number of clinical trials utilizing nicotine in PD patients have had mixed results, indicating that either nicotine is not beneficial in PD patients, or an important aspect of nicotine therapy was absent. Here we show that continuous early nicotine administration improves both climbing and flight deficiencies present in homozygous park25 mutant PD … Show more
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