Nicotine for Alzheimer's disease

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [ 23 - 24 ]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [ 25 ].…”

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [ 23 - 24 ]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [ 25 ].…”

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [23][24]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [25].…”

Nicotine enhances visual sensory processing in humans: Dose-dependent behavioral and biological evidence.

“…This question has clinical implications. Reduced cholinergic function is observed in neurodegenerative conditions such as Alzheimer’s disease (López-Arrieta & Rodríguez, 2001) and Parkinson’s disease (Liang et al, 2025), where alterations in cortical responsiveness and sensory integration are common. Experimental evidence suggests that nicotinic receptor activation can support synaptic function and modulate neural stability under stress conditions (Fernandes, Santos, & Paramei, 2020; Page et al, 2011).…”

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [ 23 - 24 ]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [ 25 ].…”

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [23][24]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [25].…”

Nicotine enhances visual sensory processing in humans: Dose-dependent behavioral and biological evidence.

“…This question has clinical implications. Reduced cholinergic function is observed in neurodegenerative conditions such as Alzheimer’s disease (López-Arrieta & Rodríguez, 2001) and Parkinson’s disease (Liang et al, 2025), where alterations in cortical responsiveness and sensory integration are common. Experimental evidence suggests that nicotinic receptor activation can support synaptic function and modulate neural stability under stress conditions (Fernandes, Santos, & Paramei, 2020; Page et al, 2011).…”

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [ 23 - 24 ]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [ 25 ].…”

Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera

“…As per the ADME study, only nicotine showed permissible values. Irrespective of favourable binding energy and the pharmacokinetics report, nicotine-based treatment needs to be taken with caution due to their significant role in enhancing tau phosphorylation [23][24]. As recorded by earlier studies, phytochemicals like bacopaside II, XII showed higher flexibility, size, and polarity [25].…”

Nicotine enhances visual sensory processing in humans: Dose-dependent behavioral and biological evidence.

“…This question has clinical implications. Reduced cholinergic function is observed in neurodegenerative conditions such as Alzheimer’s disease (López-Arrieta & Rodríguez, 2001) and Parkinson’s disease (Liang et al, 2025), where alterations in cortical responsiveness and sensory integration are common. Experimental evidence suggests that nicotinic receptor activation can support synaptic function and modulate neural stability under stress conditions (Fernandes, Santos, & Paramei, 2020; Page et al, 2011).…”