volume 10, issue 7, P1556-1574 2018
DOI: 10.18632/aging.101492
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Shun-Feng Cheng, Xun-Si Qin, Ze-Li Han, Xiao-Feng Sun, Yan-Ni Feng, Fan Yang, Wei Ge, Lan Li, Yong Zhao, Massimo De Felici, Shu-Hua Zou, Yi Zhou, Wei Shen

Abstract: In the present paper, we found that human fetal ovaries (at ~16 weeks) express the transcripts for several subunits of the nicotinic acetylcholine receptor (nAChR). Exposure to the drug in vitro resulted in the marked increase of apoptosis in the ovaries in a time and dose-dependent manner. Evidence that adverse nicotine effects are potentially due to an increased level of reactive oxygen species (ROS) and consequent DNA damage, both in the ovarian somatic cells and germ cells, are reported. After 4 days of cu…

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