Nicotine exposure during breastfeeding reduces sympathetic activity in brown adipose tissue and increases in white adipose tissue in adult rats: Sex-related differences

Peixoto, Thamara Cherem; Moura, Egberto Gaspar de; Soares, P.N.; Bertasso, Iala Milene; Pietrobon, Carla Bruna; Caramez, F.A.H.; Miranda, Rosiane Aparecida; Oliveira, Elaine de; Manhães, Alex C.; Lisboa, Patrícia Cristina

doi:10.1016/j.fct.2020.111328

Cited by 12 publications

(8 citation statements)

References 55 publications

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“…It has previously been shown that with cigarette SE only during lactation, there were decreased proteins levels of Ucp1 and Cpt1 and reduced sympathetic nerve stimulation upon BAT in female adult rat (55). The same was observed with the administration of isolated nicotine through minipumps on the dams at the same period (56). Similarly, in other rat model of SE only during lactation, SE group male adult offspring did not changed insulinemia, despite higher serum glucose levels, suggesting a pancreatic insulin secretory failure (57).…”

Section: Discussionsupporting

confidence: 61%

Maternal High Fat Diet Consumption Exaggerates Metabolic Disorders in Mice With Cigarette-Smoking Induced Intrauterine Undernutrition

et al. 2021

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Objectives: Maternal smoking causes fetal underdevelopment and results in births which are small for gestation age due to intrauterine undernutrition, leading to various metabolic disorders in adulthood. Furthermore, postnatal high fat diet (HFD) consumption is also a potent obesogenic factor, which can interact with maternal smoking. In this study, we aimed to determine whether maternal HFD consumption during pregnancy can reverse the adverse impact of maternal smoking and change the response to postnatal HFD consumption.Methods: Female mice were exposed to cigarette smoke (SE, 2 cigarettes/day) or sham exposed for 5 weeks before mating, with half of the SE dams fed HFD (43% fat, SE+HFD). The same treatment continued throughout gestation and lactation. Male offspring from each maternal group were fed the same HFD or chow after weaning and sacrificed at 13 weeks.Results: Maternal SE alone increased body weight and fat mass in HFD-fed offspring, while SE+HFD offspring showed the highest energy intake and glucose metabolic disorder in adulthood. In addition, postnatal HFD increased the body weight and aggravated the metabolic disorder caused by maternal SE and SE+HFD.Conclusions: Maternal HFD consumption could not ameliorate the adverse effect of maternal SE but exaggerate metabolic disorders in adult offspring. Smoking cessation and a healthy diet are needed during pregnancy to optimize the health outcome in the offspring.

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Section: Discussionsupporting

confidence: 61%

Maternal High Fat Diet Consumption Exaggerates Metabolic Disorders in Mice With Cigarette-Smoking Induced Intrauterine Undernutrition

et al. 2021

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“…In ↑D [195,[197][198][199][200] ↑D [201] ↑D [201] ↑D [193,197,198] ↑D [191,203,[205][206][207][208][209]214] ↑C [208] ↑D [194,203] BPA ↑ [30,44,76,87,222,225,226,229,459,699] ↓ [267] ↑ [223,224] ↑D [44,238,239,241,245,706,735] ↑D,T [31,48,51] ↑A [125,235,246] ↓A [696] ↑D [238,706] ↑A [232,…”

Section: In Vitromentioning

confidence: 99%

“…Nicotine-altered hypothalamic neuropeptides are important for appetite control in animal studies [195][196][197] and may function similarly in humans. Early-life exposure to nicotine also affected energy expenditure [198], perhaps by "whitening" of BAT that reduced BAT activity [195,199,200]. Prenatal nicotine exposure also led to elevated expression of adipogenic markers in WAT and increased storage of lipids in both WAT and peripheral tissues in rats [191,198,199,201].…”

Section: Neonicotinoid Pesticidesmentioning

confidence: 99%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

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“…54 The increase in the biosynthetic enzyme DAGL in the female offspring VAT suggests an increased 2-AG synthesis, which could be related with the higher adipocyte area as well as with the increased protein content of acetyl-CoA carboxylase and transcription factor CCAAT/enhancer-binding protein (C/EBP) beta that were previously observed in these animals. 55 It is also known that increased 2-AG biosynthesis is involved in pro-inflammatory and prostaglandin responses, mainly because it serves as substrate for cyclooxygenases. 56,57 Concerning the ECS in the adrenal gland, NIC males did not show any changes, while NIC females had higher NAPE-PLD, which could indicate higher AEA synthesis.…”

Section: Discussionmentioning

confidence: 99%

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

Miranda

Rodrigues

Peixoto

et al. 2023

J Dev Orig Health Dis

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Early nicotine exposure compromises offspring’s phenotype at long-term in both sexes. We hypothesize that offspring exposed to nicotine during breastfeeding show deregulated central and peripheral endocannabinoid system (ECS), compromising several aspects of their metabolism. Lactating rats received nicotine (NIC, 6 mg/Kg/day) or saline from postnatal day (PND) 2 to 16 through implanted osmotic minipumps. Offspring were analyzed at PND180. We evaluated protein expression of N-acylphosphatidylethanolamide-phospholipase D (NAPE-PLD), fatty acid amide hydrolase (FAAH), diacylglycerol lipase (DAGL), monoacylglycerol lipase (MAGL) and cannabinoid receptors (CB1 and/or CB2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (VAT), adrenal and thyroid. NIC offspring from both sexes did not show differences in hypothalamic ECS markers. Peripheral ECS markers showed no alterations in NIC males. In contrast, NIC females had lower liver DAGL and CB1, higher VAT DAGL, higher adrenal NAPE-PLD and higher thyroid FAAH. Endocannabinoids biosynthesis was affected by nicotine exposure during breastfeeding only in females; alterations in peripheral tissues suggest lower action in liver and higher action in VAT, adrenal and thyroid. Effects of nicotine exposure during lactation on ECS markers are sex- and tissue-dependent. This characterization helps understanding the phenotype of the adult offspring in this model and may contribute to the development of new pharmacological targets for the treatment of several metabolic diseases that originate during development.

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Nicotine exposure during breastfeeding reduces sympathetic activity in brown adipose tissue and increases in white adipose tissue in adult rats: Sex-related differences

Cited by 12 publications

References 55 publications

Maternal High Fat Diet Consumption Exaggerates Metabolic Disorders in Mice With Cigarette-Smoking Induced Intrauterine Undernutrition

Maternal High Fat Diet Consumption Exaggerates Metabolic Disorders in Mice With Cigarette-Smoking Induced Intrauterine Undernutrition

Obesity II: Establishing causal links between chemical exposures and obesity

Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood

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