Nicotine and opioid co-dependence: Findings from bench research to clinical trials

Custodio, Lilian; Malone, Samantha G.; Bardo, Michael T.; Turner, Jill

doi:10.1016/j.neubiorev.2021.12.030

Cited by 12 publications

(4 citation statements)

References 157 publications

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“…At a cellular level, the bidirectional interactions between the nicotine and opioids systems provide another argument for concurrent treatment of nicotine and opioid dependence. These cellular interactions explain in part the behavioral and physiological effects of dual use of nicotine and opioids ( 64 ). Patients in residential treatment considered being in treatment a good opportunity to attempt smoking cessation, as part of a healthier lifestyle ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

A qualitative study on people with opioid use disorders’ perspectives on smoking and smoking cessation interventions

et al. 2023

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IntroductionSmoking-related diseases are major contributors to disability and shorter life expectancy among opioid-dependent patients. Smoking prevalence is considerably higher for opioid-dependent persons than among the general population, and only a minority quit smoking in treatment settings. Studies show that pharmacological smoking cessation interventions have modest success rates. This study aimed to investigate patients’ receiving opioid agonist therapy perspectives on factors affecting behavior and decisions related to smoking cessation, and their experiences with smoking cessation.MethodsThis is a qualitative study using semi-structured individual interviews. The participants were asked, among others, to elaborate on the participants’ thoughts about smoking, previous attempts to quit tobacco use, and what could prompt a smoking cessation attempt. We analyzed the transcripts with systematic text condensation. The Standards for Reporting Qualitative Research and the Consolidated Criteria for Reporting Qualitative Research guidelines were followed. Opioid-dependent patients receiving opioid agonist therapy in outpatient clinics were invited to participate using a purposive sampling method. In total, fourteen individuals participated in this study.ResultsWe identified six themes which were: (1) reflections on how smoking affected decisions, (2) smoking and its impact on physical and mental health, (3) the economy as a motivator to stop smoking, (4) emotions, desires, and habits related to smoking, (5) knowledge of smoking, smoking cessation, and quit attempts, and (6) social factors influencing the participants’ choices and activities. The participants were well informed about the consequences of smoking and had some knowledge and experience in quitting. The participants’ pulmonary health was an important motivational factor for change. Withdrawal symptoms, anxiety, and fear of using other substances discouraged several from attempting to quit smoking. In contrast, social support from partners and access to meaningful activities were considered important factors for success. Few reported being offered help from health professionals to make a smoking cessation attempt.DiscussionExperiencing social support, being encouraged to quit smoking, and patients’ concerns for their physical health were important reasons for wanting to quit smoking. Smoking cessation interventions based on patient preferences and on the behavior change wheel may enable a higher success rate among patients receiving opioid agonist therapy.

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Section: Discussionmentioning

confidence: 99%

A qualitative study on people with opioid use disorders’ perspectives on smoking and smoking cessation interventions

et al. 2023

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“…Nicotine and opioids share a number of neural pathways that mediate their effects and they appear to act synergistically to potentiate continued and increasing use of both substances [48] . Especially important in the context of this study and the use of prescription opioid analgesics, chronic nicotine use might heighten the experience of pain as well as increase tolerance to pain medication, requiring higher dosages of pain medication to achieve pain relief among tobacco users in comparison to non-tobacco users [49] . One theory is that tobacco use disorder might be a risk factor for progression from opioid use to an OUD.…”

Section: Discussionmentioning

confidence: 99%

“…Research also shows that co-treatment of tobacco use and OUD can lead to a higher chance of abstinence and a longer period of recovery from opioid use [48] . From a treatment standpoint then, programs that address tobacco and opioid use when they co-occur might prove more effective than treating one or the other disorder although clear best-practice treatments for smoking cessation by persons with an OUD have yet to be determined [49] .…”

Section: Discussionmentioning

confidence: 99%

Mental health and substance use disorder comorbidities among Medicaid beneficiaries: Associations with opioid use disorder and prescription opioid misuse

Swartz,

Franceschini,

Scamperle

2023

AIMSPH

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<abstract><sec> <title>Background</title> Medicaid presently insures about one-fourth of the US population and disproportionately insures about 38 % of non-elderly adults with an opioid use disorder (OUD). Owing to Medicaid's prominent role insuring persons with an OUD and that Medicaid coverage includes pharmaceutical benefits, there has been considerable interest in studying potential prescription opioid misuse among Medicaid beneficiaries and identifying subpopulations at higher risk for misuse and possible progression to an OUD. </sec><sec> <title>Methods</title> The study goals were to explore the associations among prescription opioid misuse, OUD, and co-occurring mental health and other substance use disorders (SUD). We analyzed Illinois Medicaid 2018 claims data for 1102479 adult beneficiaries 18 to 64 years of age. Using algorithms based on previous studies, we first determined either the presence or absence of nine SUDS (including OUD), nine mental health disorders and likely prescription opioid misuse. Then, we subdivided the beneficiary sample into five groups: those who were prescribed opioids and evidenced either no, possible, or probable misuse; those evidencing an OUD; and those evidencing no opioid use or misuse. </sec><sec> <title>Results</title> Bivariate analyses, upset plots, and multinomial logistic regressions were used to compare the five subgroups on the prevalence of co-occurring SUDS and mental health disorders. Those with an OUD or with probable prescription opioid misuse had the highest prevalence of most co-occurring conditions with beneficiaries with an OUD the most likely to evidence co-occurring SUDS, particularly tobacco use disorder, whereas those with probable misuse had elevated prevalence rates of co-occurring mental health disorders comparable to those with an OUD. </sec><sec> <title>Conclusion</title> The medical complexity of persons with an OUD or misusing prescription opioids are considered in light of recent attempts to expand buprenorphine provision as a medication for OUD among Medicaid beneficiaries. Additionally, we consider the possibility of gender, co-occurring mental health disorders, and tobacco use disorder as important risk factors for progressing to prescription opioid misuse and an OUD. </sec></abstract>

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“…Of particular interest is the highly prevalent comorbid use of nicotine and opioids [ 21 , 22 ]. Notably, habitual use of nicotine containing products among individuals seeking treatment for an opioid use disorder (OUD) is estimated to be at a rate between 74 and 97% [ 23 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Adolescent nicotine exposure promotes adulthood opioid consumption that persists despite adverse consequences and increases the density of insular perineuronal nets

Honeycutt,

Mukherjee,

Paladino

et al. 2024

Addiction Neuroscience

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Nicotine and opioid co-dependence: Findings from bench research to clinical trials

Cited by 12 publications

References 157 publications

A qualitative study on people with opioid use disorders’ perspectives on smoking and smoking cessation interventions

A qualitative study on people with opioid use disorders’ perspectives on smoking and smoking cessation interventions

Mental health and substance use disorder comorbidities among Medicaid beneficiaries: Associations with opioid use disorder and prescription opioid misuse

Adolescent nicotine exposure promotes adulthood opioid consumption that persists despite adverse consequences and increases the density of insular perineuronal nets

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