Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS

Alasmari, Fawaz; Alasmari, Abdullah F.; Elzayat, Ehab M.; Alotaibi, Majed A.; Alotaibi, Farraj M; Attwa, Mohamed W.; Alanazi, Fars K.; Abdelgadir, Elkhatim H.; Ahmad, Syed Rizwan; Alqahtani, Faleh; Al-Rejaie, Salim S.; Alshammari, Musaad A.

doi:10.15537/smj.2022.43.7.20220142

Cited by 5 publications

(1 citation statement)

References 30 publications

(63 reference statements)

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“…In almost all cases, particularly in central nervous system responses, the presence of nicotine in vaping fluids exacerbated the effects [94,95,[103][104][105]108]. Not surprisingly, sexdependent effects were found, whereby female adolescent rats displayed lower anxiolytic effects and were more sensitive to the rewarding effect of nicotine than their male counterparts [93,139,140], although others did not find sex differences [107].…”

Section: Central Nervous Systemmentioning

confidence: 99%

Sex Differences in E-Cigarette Use and Related Health Effects

Alam,

Silveyra

2023

IJERPH

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Background: Electronic cigarettes (e-cigarettes) comprise a variety of products designed to deliver nicotine, flavorings, and other substances. To date, multiple epidemiological and experimental studies have reported a variety of health issues associated with their use, including respiratory toxicity, exacerbation of respiratory conditions, and behavioral and physiological effects. While some of these effects appear to be sex- and/or gender-related, only a portion of the research has been conducted considering these variables. In this review, we sought to summarize the available literature on sex-specific effects and sex and gender differences, including predictors and risk factors, effects on organ systems, and behavioral effects. Methods: We searched and selected articles from 2018–2023 that included sex as a variable or reported sex differences on e-cigarette-associated effects. Results: We found 115 relevant studies published since 2018 that reported sex differences in a variety of outcomes. The main differences reported were related to reasons for initiation, including smoking history, types of devices and flavoring, polysubstance use, physiological responses to nicotine and toxicants in e-liquids, exacerbation of lung disease, and behavioral factors such as anxiety, depression, sexuality, and bullying. Conclusions: The available literature supports the notion that both sex and gender influence the susceptibility to the negative effects of e-cigarette use. Future research needs to consider sex and gender variables when addressing e-cigarette toxicity and other health-related consequences.

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