Nicotine and caffeine: Disruption of the long-term store of memory and proactive facilitation of learning in mice

Stripling, Jeffrey S.; Alpern, Herbert P.

doi:10.1007/bf00421371

Cited by 13 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A dose of nicotine which disrupted acquisition of an active avoidance task (0.8 mg/kg) enhanced maze learning when administered after training trials (Garg 1969;Garg and Holland 1969). Post-training injection of 2.0 mg/kg nicotine disrupted the retention of a brightness discrimination maze, but facilitated acquisition when the same dose was administered before training to naive animals (Stripling and Alpern 1974). Post-training administration of nicotine (0.4-1.6 mg/kg) has also been shown to improve retention as measured by habituation of exploratory activity (Platel and Porsolt 1982).…”

mentioning

confidence: 99%

Actions of nicotine on the acquisition of an autoshaped lever-touch response in rats

Mundy

Iwamoto

1988

Psychopharmacology

View full text Add to dashboard Cite

Experimentally naive male, Sprague-Dawley rats maintained at 85% of their original body weight were trained to touch a retractable lever that was presented on a random interval 48-s schedule. The lever retracted when touched or after 15 s had elapsed, and one 45 mg food pellet was delivered simultaneously with lever retraction or after an 8-s delay. Rats received ten daily sessions each consisting of ten lever presentations. Nicotine (0.25-0.8 mg/kg SC) administration, either 15 min prior to (pre-session) or immediately after (post-session) the daily autoshaping sessions, caused a significant dose-related impairment of acquisition with the post-session injections having the greater effect. Low doses of nicotine (0.025-0.1 mg/kg SC) had little effect on acquisition when injected pre-session or post-session. Injections of 0.45 mg/kg nicotine either immediately (t = 0) or at +5 min after the daily sessions impaired acquisition of the lever-touch response. Nicotine injected at +15, +30, +60, or +120 min had no effect on acquisition. A single intraventricular injection of the ganglionic blocker chlorisondamine (5 micrograms) 2 weeks prior to autoshaping blocked the impairment produced by 0.45 mg/kg nicotine. Post-session injections of nicotine did not alter the lever-touch behavior of well-trained animals, but suppressed responding in animals that were partially trained. Thus, nicotine-induced impairment of the autoshaped lever-touch response is dose dependent, centrally mediated, occurs within 5 min of a SC injection, and may interfere with post-training consolidation processes.

show abstract

mentioning

confidence: 99%

Actions of nicotine on the acquisition of an autoshaped lever-touch response in rats

Mundy

Iwamoto

1988

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Caffeine

Estler¹

1982

Psychotropic Agents

View full text Add to dashboard Cite

Effects of nicotine on discrimination learning, consolidation and learned behaviour in two inbred strains of mice

Castellano

1976

Psychopharmacology

View full text Add to dashboard Cite

DBA/2J and C57BL/6J mice were injected with nicotine, and tested in a Y water maze in two procedures: the L procedure, coresponding to innate behavior, in which the animals must swim towards the light, and the D procedure, corresponding to the acquisition of a new pattern of behavior, in which they must swim toward the dark. Three sets of experiments were carried out: 1. In the pre-trial experiments, nicotine administration improved the innate tendencies of both strains, while the acquisition of a new behavior was facilitated in the C57 and impaired in the DBA mice. 2. In the post-trial experiments (D procedure), nicotine administration induced clear facilitating effects on the consolidation processes of the C57, while impairing these processes in the DBA strain. 3. The only effect evident, following nicotine administration, before the highest doses were reached, in the trained mice of both strains, was a performance impairment of the DBA mice trained in the L procedure.

show abstract

Nicotine and caffeine: Disruption of the long-term store of memory and proactive facilitation of learning in mice

Cited by 13 publications

References 50 publications

Actions of nicotine on the acquisition of an autoshaped lever-touch response in rats

Actions of nicotine on the acquisition of an autoshaped lever-touch response in rats

Caffeine

Effects of nicotine on discrimination learning, consolidation and learned behaviour in two inbred strains of mice

Contact Info

Product

Resources

About