Nicotine Ameliorates Experimental Severe Acute Pancreatitis via Enhancing Immunoregulation of CD4+ CD25+Regulatory T Cells

Zheng, Yongping; Wu, Zongsheng; Zhang, Luyao; Ke, Lu; Li, Weiqin; Li, Ning; Li, Jieshou

doi:10.1097/mpa.0000000000000294

Cited by 25 publications

(34 citation statements)

References 23 publications

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“…A more recent report confirmed that Tregs could specifically suppress cytotoxic T cell response [10], which was very important in pancreas tissue destruction of chronic pancreatitis patients [9]. The suppressive effects of Tregs on cytotoxic T cells were IL-10 dependent [10, 26]. Similarly, in our study, we found that decreased Tregs in chronic pancreatitis mice (Figs.…”

Section: Discussionsupporting

confidence: 78%

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

Chen

Bian

et al. 2017

Cell Physiol Biochem

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Background/Aims: Chronic pancreatitis is an inflammatory disease of the pancreas characterized by progressive tissue destruction and fibrogenesis. The development of chronic pancreatitis is associated with immune cell dysregulation. Currently, the specific and effective treatment of chronic pancreatitis remains absent. Methods: By using an L-arginine induced chronic pancreatitis mouse model, we tested the therapeutic potential of hydrogen, a strong hydroxyl radicals scavenger, in the chronic pancreatitis model. Tissue inflammation, damage and fibrosis were analyzed on HE, TUNEL, MPO, and sirius staining. Pancreas levels of MDA content, SOD activity, TNF-α , IL-10 cytokine expression and serum amylase and lipase activity were determined by ELISA and absorbance assay. Apoptosis, T cells subtype proportion and intracellular level of reactive oxygen species (ROS) were analyzed by flow cytometry. Tregs adoptive transfer and CD25 neutralization were used to validate the role of Tregs in chronic pancreatitis. Results: We found that hydrogen treatment significantly improved multiple symptoms of chronic pancreatitis. The number of Tregs was reduced in chronic pancreatitis mice, while hydrogen treatment restored the Treg loss by L-arginine administrations. Depletion of Tregs abolished the protective effect of hydrogen treatment in chronic pancreatitis. In vitro study showed that hydrogen blocked ROS generation in Tregs and promoted Tregs survival. Conclusion: Hydrogen treatment showed reliable benefits in controlling the severity of chronic pancreatitis. Our study supported that hydrogen could be used as a novel treatment in chronic pancreatitis patient in the future.

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Section: Discussionsupporting

confidence: 78%

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

Chen

Bian

et al. 2017

Cell Physiol Biochem

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“…These findings are in sharp contrast to the overwhelming data supporting an independent effect of smoking and pancreatitis development (33,51,61,63,71,92,107,108,125,126). In this study the authors reason that potential racial differences in nicotine metabolism and susceptibility to smoking between the Taiwanese populations they examined versus ethnically different populations from the other investigations, may account for the discrepancy.…”

Section: Role Of Tobacco In Development Of Pancreatic Disease: Pancrecontrasting

confidence: 56%

“…Although these studies imply tobacco use potentiates alcohol effects in pancreatitis convincing data has emerged from several casecontrol and cohort studies strongly supporting an independent association between smoking and pancreatitis (33,51,61,63,71,92,107,108,125,126). The major findings from these studies are detailed in Table 1.…”

Section: Role Of Tobacco In Development Of Pancreatic Disease: Pancrementioning

confidence: 89%

“…Collectively, evidence from these clinical studies supports a dose-dependent association between smoking and chronic pancreatitis; however, a similar association with acute pancreatitis (AP) has also been revealed (18,108,126). In a Danish study with a mean follow-up of 20.2 years, a link between smoking and increased risk of AP was observed, independent of alcohol consumption.…”

Section: Role Of Tobacco In Development Of Pancreatic Disease: Pancrementioning

confidence: 94%

“…In addition to the Danish and American studies, a population-based cross-sectional study of the elderly Chinese population has linked tobacco consumption with the risk of AP, particularly in those who have smoked at least 15 pack years (125). Furthermore, systematic review and metaanalyses, which include many of the studies detailed here, find conclusively that current smoking and former smoking are firmly connected with elevated risk for AP (6,126). One singlecenter prospective, cohort study of the natural history of AP, found that smoking was a dosedependent risk factor for recurrent acute pancreatitis (RAP) (18).…”

Section: Role Of Tobacco In Development Of Pancreatic Disease: Pancrementioning

confidence: 99%

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Smoking induced pancreatitis and pancreatic cancer

Edderkaoui¹

The Pancreapedia: Exocrine Pancreas Knowledge Base

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Abstract:Acute pancreatitis, chronic pancreatitis, and pancreatic cancer are three major pancreatic diseases without any effective treatment. In this character, the latest knowledge regarding the association between these diseases and tobacco smoking is reviewed. Clinical evidence of the association is presented, followed by an overview of scientific evidence, and the potential pathways that mediate smoking-induced pancreatitis and pancreatic cancer.

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From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury

Liu,

Zhu,

Guo

2024

Immunity Inflam & Disease

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BackgroundSevere acute pancreatitis (SAP) is a potentially lethal inflammatory pancreatitis condition that is usually linked to multiple organ failure. When it comes to SAP, the lung is the main organ that is frequently involved. Many SAP patients experience respiratory failure following an acute lung injury (ALI). Clinicians provide insufficient care for compounded ALI since the underlying pathophysiology is unknown. The mortality rate of SAP patients is severely impacted by it.ObjectiveThe study aims to provide insight into immune cells, specifically their roles and modifications during SAP and ALI, through a comprehensive literature review. The emphasis is on immune cells as a therapeutic approach for treating SAP and ALI.FindingsImmune cells play an important role in the complicated pathophysiology ofSAP and ALI by maintaining the right balance of pro‐ and anti‐inflammatory responses. Immunomodulatory drugs now in the market have low thepeutic efficacy because they selectively target one immune cell while ignoring immune cell interactions. Accurate management of dysregulated immune responses is necessary. A critical initial step is precisely characterizing the activity of the immune cells during SAP and ALI.ConclusionGiven the increasing incidence of SAP, immunotherapy is emerging as a potential treatment option for these patients. Interactions among immune cells improve our understanding of the intricacy of concurrent ALI in SAP patients. Acquiring expertise in these domains will stimulate the development of innovative immunomodulation therapies that will improve the outlook for patients with SAP and ALI.

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Nicotine Ameliorates Experimental Severe Acute Pancreatitis via Enhancing Immunoregulation of CD4+ CD25+Regulatory T Cells

Abstract: Modulating immunoregulation of CD4 CD25 Treg is a critical mechanism for nicotinic anti-inflammatory pathway and it may be feasible to use selective agonists as an immunotherapy for SAP.

Cited by 25 publications

References 23 publications

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

Smoking induced pancreatitis and pancreatic cancer

From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury

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