Nicotine alters the expression of molecular markers of endocrine disruption in zebrafish

Kanungo, Jyotshna; Cuevas, Elvis; Guo, Xiaoqing; Lopez, A.; Ramirez-Lee, Manuel Alejandro; Trickler, William J.; Paule, Merle G.; Ali, Syed F.

doi:10.1016/j.neulet.2012.08.027

Cited by 29 publications

(14 citation statements)

References 41 publications

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“…Nicotine has been determined to have anti-estrogenic effects and decrease the production of estrogen [30, 31], therefore, comparing with nonsmoker, menopause would occur approximately 2 years earlier in female smokers [32] and the age of menopause was recognized as a significant indicator of osteoporosis [33]. However, although some articles support that the level of testosterone in male smokers is higher than nonsmokers, the testosterone tend to influence metabolism of bone in man has not been well defined than the relative effect of estrogen in woman [29,34].…”

Section: Discussionmentioning

confidence: 99%

Effect of Cigarette Smoking on Risk of Hip Fracture in Men: A Meta-Analysis of 14 Prospective Cohort Studies

Zhao

Liu

et al. 2016

PLoS ONE

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BackgroundSeveral observational studies have suggested an association between cigarette smoking and risk of hip fracture. However, no formal systematic review or meta-analysis was performed to summarize this risk in men.Materials and MethodsA search was applied to MEDLINE, EMBASE, and web of science (up to November 1 2016). All prospective cohort studies assessing risk of hip fracture with the factor of cigarette smoking in men without language restriction were reviewed, and qualities of all included studies were assessed using the Newcastle-Ottawa Scale. Two authors independently assessed literatures and extracted information eligibility, and any disagreement was resolved by consensus. Newcastle-Ottawa quality assessment scale was used to evaluate studies’ quality in meta-analyses. We calculated the RR with 95% CIs in a random-effects model as well as the fixed-effects model using the metan command in the STATA version 12.0 (StataCorp, USA).ResultsFourteen prospective cohort studies were eligible for the present analysis. A meta-analysis of 12 prospective studies showed that the relative risk (RR) for current male smoking was 1.47 [95% confidence interval (CI) (1.28–1.66), p = 0.54; I2 = 0%]. Subgroup analyses show study characteristics (including geography region, length of follow-up, size of cohorts and study quality) did not substantially influence these positive associations. Eight studies reported the RRs for former smokers compared with never smokers and the pooled RR was 1.15 [95% CI, (0.97–1.34), (I2 = 0%, p = 0.975)].ConclusionsThe present meta-analysis of 14 prospective studies suggests that, compared with never smokers, cigarette smoking increases risk of hip fracture in man, specifically in current smokers. However, further larger prospective cohorts with more power or meta-analysis of individual patient data are needed to confirm this association.

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Section: Discussionmentioning

confidence: 99%

Effect of Cigarette Smoking on Risk of Hip Fracture in Men: A Meta-Analysis of 14 Prospective Cohort Studies

Zhao

Liu

et al. 2016

PLoS ONE

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“…Smoking is associated with lower body mass [40], earlier onset of menopause [8], aggravation of oxidative stress [41], and a more unhealthy and sedentary lifestyle. The effect of smoking on bone mineral density (BMD) and fractures may be resulted from changes of serum estradiol levels [9], serum parathyroid level [11] and serum vitamin D level [12], consequently affecting gastrointestinal calcium absorption and bone cells proliferation [42], and thus exerting an inhibitory effect on BMD and bone metabolism. There is evidence that nicotine reduce oestrogen production and enhances the hepatic metabolism of estradiol [9].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of smoking on bone mineral density (BMD) and fractures may be resulted from changes of serum estradiol levels [9], serum parathyroid level [11] and serum vitamin D level [12], consequently affecting gastrointestinal calcium absorption and bone cells proliferation [42], and thus exerting an inhibitory effect on BMD and bone metabolism. There is evidence that nicotine reduce oestrogen production and enhances the hepatic metabolism of estradiol [9]. The parathyroid hormone and vitamin D axis plays a synergistic role in stimulating osteoclast proliferation and bone mineralization [11].…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking and risk of hip fracture in women: A meta-analysis of prospective cohort studies

Shen

Zhao

et al. 2015

Injury

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“…Nicotine can also be considered an endocrine disruptor (Kanungo et al 2012); so we have to consider that endocrine disruptors acting in the fetal stage can cause reproductive damage, which will be observed in adulthood due to injury to not only Leydig cells but also to Sertoli cells (Richburg & Dwyer 2010). Our group has found that the exposure to nicotine early in life causes morphological changes of the Leydig cells in the adult offspring (Paccola et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Prenatal and lactation nicotine exposure affects Sertoli cell and gonadotropin levels in rats

Paccola¹,

Miraglia²

2016

Reproduction

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Nicotine is largely consumed in the world as a component of cigarettes. It can cross the placenta and reach the milk of smoking mothers. This drug induces apoptosis, affects sex hormone secretion, and leads to male infertility. To investigate the exposure to nicotine during the whole intrauterine and lactation phases in Sertoli cells, pregnant rats received nicotine (2 mg/kg per day) through osmotic minipumps. Male offsprings (30, 60, and 90 days old) had blood collected for hormonal analysis (FSH and LH) and their testes submitted for histophatological study, analysis of the frequency of the stages of seminiferous epithelium cycle, immunolabeling of apoptotic epithelial cells (TUNEL and Fas/FasL), analysis of the function and structure of Sertoli cells (respectively using transferrin and vimentin immunolabeling), and analysis of Sertoli-germ cell junctional molecule (b-catenin immunolabeling). The exposure to nicotine increased the FSH and LH plasmatic levels in adult rats. Although nicotine had not changed the number of apoptotic cells, neither in Fas nor FasL expression, it provoked an intense sloughing of epithelial cells and also altered the frequency of some stages of the seminiferous epithelium cycle. Transferrin and b-catenin expressions were not changed, but vimentin was significantly reduced in the early stages of the seminiferous cycle of the nicotine-exposed adult rats. Thus, we concluded that nicotine exposure during all gestational and lactation periods affects the structure of Sertoli cells by events causing intense germ cell sloughing observed in the tubular lumen and can compromise the fertility of the offspring.

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Nicotine alters the expression of molecular markers of endocrine disruption in zebrafish

Cited by 29 publications

References 41 publications

Effect of Cigarette Smoking on Risk of Hip Fracture in Men: A Meta-Analysis of 14 Prospective Cohort Studies

Effect of Cigarette Smoking on Risk of Hip Fracture in Men: A Meta-Analysis of 14 Prospective Cohort Studies

Cigarette smoking and risk of hip fracture in women: A meta-analysis of prospective cohort studies

Prenatal and lactation nicotine exposure affects Sertoli cell and gonadotropin levels in rats

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