Nicotinamide Riboside Delivery Generates Nad+ Reserves to Protect Vascular Cells Against Oxidative Damage

Hawrylyshyn, Krista; Yin, Hao; O’Neil, Caroline; Watson, Alanna; Pickering, J. Geoffrey

doi:10.1016/j.cjca.2015.07.477

Cited by 4 publications

(5 citation statements)

References 244 publications

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“…Unlike NAM, the administration of other dietary vitamin B 3 -related metabolites (i.e., NMN and NR) has previously been reported to protect the vasculature from oxidative stress [ 22 , 23 ]. As NMN and NR are NAD+ intermediaries [ 54 ], this effect might be at least partially attributed to SIRT1 signaling in target tissues [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dietary supplementation with other vitamin B 3 derivatives, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), confer favorable age-related vasoprotective effects by reversing endothelial dysfunction, attenuating oxidative stress, or rescuing age-related changes in gene expression [ 21 , 22 , 23 , 24 , 25 ]. However, these favorable effects have not been linked to changes in the inflammatory status of target tissues in these studies.…”

Section: Introductionmentioning

confidence: 99%

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Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

et al. 2020

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The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic atherosclerosis was significantly reduced (NAM low dose: 45%; NAM high dose: 55%) in NAM-treated, apolipoprotein (Apo)E-deficient mice challenged with a Western diet for 4 weeks. NAM administration significantly increased (1.8-fold) the plasma concentration of proatherogenic ApoB-containing lipoproteins in NAM high-dose (HD)-treated mice compared with untreated mice. However, isolated ApoB-containing lipoproteins from NAM HD mice were less prone to oxidation than those of untreated mice. This result was consistent with the decreased (1.5-fold) concentration of oxidized low-density lipoproteins in this group. Immunohistochemical staining of aortas from NAM-treated mice showed significantly increased levels of IL-10 (NAM low-dose (LD): 1.3-fold; NAM HD: 1.2-fold), concomitant with a significant decrease in the relative expression of TNFα (NAM LD: −44%; NAM HD: −57%). An improved anti-inflammatory pattern was reproduced in macrophages cultured in the presence of NAM. Thus, dietary NAM supplementation in ApoE-deficient mice prevented the development of atherosclerosis and improved protection against ApoB-containing lipoprotein oxidation and aortic inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

et al. 2020

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“…Other vitamin B3 intermediates, such as NMN and NR, reversed age-related endothelial dysfunction and reduced oxidative stress [ 15 , 28 ]. Although their mechanism of action in atherosclerosis prevention has not been directly evaluated in vivo, the effects of these intermediates can be at least partly explained by their ability to effectively increase the tissue content of NAD+ and, thus, restore SIRT1 activity (reviewed in reference [ 8 ]).…”

Section: In Vivo Cardiovascular Effects Of Nad+-boosting Strategies: Lessons From Animal Modelsmentioning

confidence: 99%

“…Recent data from our own group show that NAM prevents inflammation and atherosclerosis in experimental animals [ 25 ]. Similarly, some other related compounds, such as NR [ 28 ], NMN [ 9 ], and N-methylated NAM (me-NAM) [ 29 , 30 ], seem to protect against vascular damage.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases

et al. 2021

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Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. NAD+ bioavailability decreases with age and cardiometabolic conditions in several mammalian tissues. Compelling data suggest that declining tissue NAD+ is commonly related to mitochondrial dysfunction and might be considered as a therapeutic target. Thus, NAD+ replenishment by either genetic or natural dietary NAD+-increasing strategies has been recently demonstrated to be effective for improving the pathophysiology of cardiac and vascular health in different experimental models, as well as human health, to a lesser extent. Here, we review and discuss recent experimental evidence illustrating that increasing NAD+ bioavailability, particularly by the use of natural NAD+ precursors, may offer hope for new therapeutic strategies to prevent and treat cardiovascular diseases.

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“…Therefore, the unanswered metabolic needs cause an anatomical response with means of a series of growth factors that probably have high importance. 15 This step starts approximately from Day 4 or 5. During healing, fibroplasia (fibroblast proliferation) is stimulated from various mechanisms that start with secretion of PDFG, IGF-1, and TGFβ from platelets and resumes with the secretion of cytokines from the macrophage.…”

Section: Introductionmentioning

confidence: 99%

Investigating the healing effect of the hydroalcoholic extract of pomegranate seed (Punica granatum) on the full thickness wound in rabbit

Hemmati

Rashidi

Dahanzadeh

et al. 2020

J. Contemp. Med. Sci.

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Objective: This research designed to investigate the wound healing process with pomegranate hydroalcoholic seed extract (Punica granatum) in comparison with no-treatment, betamethasone, phenytoin and eucerin in rabbits. Methods: The positive group including groups that received phenytoin cream (1%) and topical eucerin, respectively, twice a day to complete wound healing. negative Control group did not obtain any treatment. Treatment groups were received cream of PSE (2, 5,7,10 w/w) in eucerin and 75% w/w as purified extract twice daily. In order to measure the percentage of wound healing, the zone of the wound was evaluated daily. Histological studies were done on the 7th and 15th days of treatment. Next, hydroxyproline content of wounds healed and tensile strength of wound tissue samples were measured. Results: The results demonstrated between PSE treatment groups and eucerin animals were statistically significant aadifferences (P<0.05) in most of the days reviewed. Treatment of Rabbits with 10% PSE had the best results (complete wound recovery in 12 days). Also, this treatment showed higher hydroxyproline content and higher tissue strength. Conclusion: This research reveals that the extract of 10% PSE administrated topically has the proper potential to induce wound recovery in the wound model of rabbits. In addition, 10% PSE accelerates the healing of the wound. Further study needs to clarify the results of this research.

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Nicotinamide Riboside Delivery Generates Nad+ Reserves to Protect Vascular Cells Against Oxidative Damage

Abstract: The ability of vascular cells to withstand oxidative insults is critical to vascular health.

Cited by 4 publications

References 244 publications

Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases

Investigating the healing effect of the hydroalcoholic extract of pomegranate seed (Punica granatum) on the full thickness wound in rabbit

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