“…The perinatal asphyxia model, intra-uterus oxygen deprivation, causes non-spatial working memory deficits, increased apoptosis in the whole hippocampus at 30-45 days, increased mossy fiber sprouting in dorsal hippocampus and increased anxiety behavior at 90 days (Morales, Simola et al 2010). In the neonatal anoxia model, used in the present research, acute hippocampal cell death, spatial memory and learning deficits in adult rats were observed after oxygen deprivation (Takada, dos Santos Haemmerle et al 2015).…”