Nicotinamide fumaric acid supramolecular cocrystals: diversity of stoichiometry

Synthesis Characterization Molecular Modeling of a Pharmaceutical Co-Crystal: (2-Chloro-4-Nitrobenzoic Acid):(Nicotinamide)

“…LAG experiments can produce the desired co‐crystal in very little time, from 5 to 20 min, and may yield the same and/or different crystal forms of the resulting co‐crystal. A number of co‐crystals with nic have been prepared in this manner 60, 69. A rapid method to establish the potential for co‐crystal formation is the so‐called Kofler contact method of thermal microscopy 70–72.…”

Mechanochemistry: opportunities for new and cleaner synthesis

“…This was demonstrated in screening for cocrystals of the model API nicotinamide with dicarboxylic acids: Screening from the melt was not possible with thermally sensitive oxalic acid, [184] or the high melting fumaric acid. [191] Another potentially interesting role for LAG in the context of pharmaceutical solids is for conducting cocrystal-cocrystal reactions involving chiral and racemic solid forms. In particular, LAG reactions between left-and right-handed pharmaceutical cocrystals of theophylline with tartaric acid were found to give a racemic pharmaceutical cocrystal.…”

Cocrystal Systems of Pharmaceutical Interest: 2009

“…Structures of the cocrystal products, and identification of 3 supramolecular synthons useful for the prediction of structural motifs [61] Glutaric acid Urea Discovery of a new 1:1 cocrystal by construction of the ternary phase diagram [62] Fumaric acid Nicotinamide Characterization of the amide-acid heterosynthon in the 1:1 cocrystal and the amide-amide homosynthon in the 2:1 cocrystal [63] Cyanooxime compounds N-heterocycle compounds Study of the versatility of cyanooximes as hydrogen-bond donors when interacted with asymmetric ditopic N-heterocyclics 4-Aminobenzyl alcohol 4-Acetylpyridine Structural analysis of the 1:1 cocrystal, as well as the structures of several related compounds [69] 4-p-Hydroxyphenyl-2,2,4-trimethyl-chroman…”