Nicotianamine-rich foods for improving the learning and memory functions and as an effective preventing agent of hypertension

Takada, Noboru; Tanaka, Masayuki; Ishidoya, Ayumi; Hayakari, Makoto

doi:10.1016/j.fbio.2020.100729

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Notably, NA can play a pivotal role in Fe trafficking in the mammalian intestine, as Fe(II)–NA can be absorbed by proton-coupled amino acid transporter 1 (PAT1) in the proximal jejunum [ 53 , 249 ]. Nicotianamine-rich foods are proposed to improve the quality of life of patients with Alzheimer disease via relieving hypertension as well as for the enhancement of the learning and memory functions [ 250 ].…”

Section: Conclusion Perspectives and Outlookmentioning

confidence: 99%

Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants

Серегин

Кожевникова

2023

IJMS

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Nicotianamine (NA) is a low-molecular-weight N-containing metal-binding ligand, whose accumulation in plant organs changes under metal deficiency or excess. Although NA biosynthesis can be induced in vivo by various metals, this non-proteinogenic amino acid is mainly involved in the detoxification and transport of iron, zinc, nickel, copper and manganese. This review summarizes the current knowledge on NA biosynthesis and its regulation, considers the mechanisms of NA secretion by plant roots, as well as the mechanisms of intracellular transport of NA and its complexes with metals, and its role in radial and long-distance metal transport. Its role in metal tolerance is also discussed. The NA contents in excluders, storing metals primarily in roots, and in hyperaccumulators, accumulating metals mainly in shoots, are compared. The available data suggest that NA plays an important role in maintaining metal homeostasis and hyperaccumulation mechanisms. The study of metal-binding compounds is of interdisciplinary significance, not only regarding their effects on metal toxicity in plants, but also in connection with the development of biofortification approaches to increase the metal contents, primarily of iron and zinc, in agricultural plants, since the deficiency of these elements in food crops seriously affects human health.

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Section: Conclusion Perspectives and Outlookmentioning

confidence: 99%

Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants

Серегин

Кожевникова

2023

IJMS

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“…Crop-derived bioactive compounds have been shown to improve mineral bioavailability, possess antiin ammatory properties, and positively modulate the gut microbiome 12,[31][32][33][34] . Nicotianamine (NA), a nonprotein amino acid-derived plant metabolite, is a naturally occurring chelator of iron (Fe), zinc (Zn), and other transition metals in higher plants and is involved in metal translocation between plant cells, tissues and organs 35,36 .…”

Section: Introductionmentioning

confidence: 99%

Constitutive overexpression of a nicotianamine synthase gene in bread wheat and in vivo assessment of iron and zinc bioavailability

Tako,

Cheng,

Beasley

et al. 2024

Preprint

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Iron (Fe) and zinc (Zn) deficiencies affect over two billion people globally. Biofortification of bread wheat (Triticum aestivum), a crop that supplies approximately 20% of calories and protein consumed by humans worldwide, represents a sustainable strategy for increasing micronutrient intakes. We employed constitutive overexpression (OE) of an endogenous nicotianamine synthase gene (TaNAS2A) in bread wheat cultivar Gladius to increase biosynthesis of the metal-chelating molecule nicotianamine (NA). Field evaluation of three independent OE-TaNAS2A events found normal growth and consistently increased NA concentration in whole wheat flour relative to controls. Extracts prepared from whole wheat flours were functionally characterized in vivo (Gallus gallus) using the intraamniotic administration approach and alterations in markers of Fe and Zn transport, inflammation, and intestinal functionality and morphology were observed in treatment groups that received OE-TaNAS2A extracts.

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Targeting brain health: Whey protein hydrolysate intervention enhances cognitive function in middle-aged mice

Ding,

Meng,

et al. 2024

Food Bioscience

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Nicotianamine-rich foods for improving the learning and memory functions and as an effective preventing agent of hypertension

Cited by 3 publications

References 36 publications

Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants

Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants

Constitutive overexpression of a nicotianamine synthase gene in bread wheat and in vivo assessment of iron and zinc bioavailability

Targeting brain health: Whey protein hydrolysate intervention enhances cognitive function in middle-aged mice

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