Nicotiana tabacum L.: Tobacco

Lewis, Ramsey S.

doi:10.1007/978-3-030-38792-1_9

Cited by 10 publications

(5 citation statements)

References 111 publications

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“…Over the past several decades, the cultivation and utilization of tobacco (Nicotiana tabacum) have predominantly been driven by its nicotine content, which is associated with a multitude of health risks(6, 7). However, as scientific inquiry advances, a more nuanced understanding of tobacco’s pharmacological potential has revealed a plethora of compounds beyond nicotine that may confer therapeutic and health benefits(8, 9).…”

Section: Introductionmentioning

confidence: 99%

“…Nicotine, a principal constituent of tobacco, has been shown to ameliorate neural damage and elicit anti-inflammatory responses in glial cells(12). Furthermore, non-nicotine compounds present in tobacco, including rutin, chlorogenic acid, and solanine, have been recognized for their antioxidative, anti-inflammatory, and neuroprotective properties(6, 13-15). These insights offer a fresh perspective on assessing the economic value and potential applications of tobacco.…”

Section: Introductionmentioning

confidence: 99%

“…These insights offer a fresh perspective on assessing the economic value and potential applications of tobacco. In this context, tobacco producer becomes significant potentials for drug screening specifically for the treatment of neurodegenerative diseases, given its abundant and largely untapped tobacco leaf resources (6, 14, 16). Nevertheless, there remains a research gap in fully understanding the complex cellular processes of the human brain in relation to these compounds.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

Liao,

Li,

et al. 2024

Preprint

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Neurodegenerative diseases have emerged as major global health challenges, particularly in the context of an increasingly aging population. Traditionally, tobacco has been associated with various health risks, but recent research is uncovering a different aspect of this plant, suggesting that it may contain compounds with potential therapeutic benefits for neurodegenerative conditions. In this study, we have delved into the potential of specific bioactive compounds found in tobacco to serve as neuroprotective agents in the context of AD. Leveraging genetic engineering, we have developed a novel approach using neural progenitor cells (NPCs) derived from embryonic stem cells, equipped with an NF-κB reporter system. This system was instrumental in screening and identifying bioactive tobacco extracts. Our screenings revealed three compounds that exhibited significant inhibitory effects on NF-κB activation, a key mediator of neuroinflammation implicated in AD pathology. Among these compounds, rutin stood out for its profound neuroprotective effects in an NPC damage model induced by Amyloid-β25-35. These effects were manifested through a reduction in apoptotic cell death, an enhancement in cellular proliferation, and the activation of critical survival signaling pathways. This modulation is suggested to underlie rutin’s anti-inflammatory and neuroprotective activities. These findings not only provide a scientific rationale for the application of tobacco-derived active molecules in AD therapy but also lay the foundation for exploration of their pharmaceutical value.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

Liao,

Li,

et al. 2024

Preprint

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“…The plant is cultivated primarily for use in the manufacture of nicotine-containing products such as cigarettes [5]. Nicotine which is the main active principle in the plant has been reported to be the most common overused compound in the world [4].…”

Section: Introductionmentioning

confidence: 99%

Cow Urine Extract of Nicotiana tabacum Leaf Portends Hepatotoxicity in Male Wistar Rats

Yusuf¹,

Lukman²,

Okeme³

et al. 2023

IJBcRR

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Aims: The toxicological effects of single and repeated doses of aqueous extract (AE) and cow urine extract (CUE) of Nicotiana tabacum leaf on the liver and kidney function indices of male Wistar rats were investigated. Study Design: Thirty-five male rats were randomized into seven groups (n=5). The control group received 0.5 mL of distilled water, groups A and B received 8 mg/kg body weight (BW) of CUE and AE respectively, once daily; groups C and D received 16 mg/kg BW of CUE and AE respectively, thrice a day (TD); groups E and F received 32 mg/kg BW of CUE and AE respectively, TD.The administration was oral and lasted for 28 days. Place and Duration of Study: The study was carried out at Summit University, Offa, Nigeria between June 2019 and August 2019. Methodology: Thirty-five male rats were randomized into seven groups (n=5). The control group received 0.5 mL of distilled water, groups A and B received 8 mg/kg body weight (BW) of CUE and AE respectively, once daily; groups C and D received 16 mg/kg BW of CUE and AE respectively, thrice a day (TD); groups E and F received 32 mg/kg BW of CUE and AE respectively, TD. Results: The result revealed no significant difference in the activities of the ALP, and GGT but a significant increase in the ACP, ALT, and AST activities in both tissues and serum. Furthermore, there was a significant decrease in albumin concentration of rats in all the groups except group B when compared with the control rats. Liver and kidney histology revealed minimal lymphocytic infiltration with no sign of medium-term systemic damage. Conclusion: The study suggests no nephrotoxicity of AE and CUE at all doses administered, but probable hepatotoxicity at higher and repeated doses of both extracts except at the single dose of 8 mg/kg BW of AE.

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“…This includes the requisite that a candidate cultivar exhibit percent total alkaloids (PTA) within a specific range defined by two long‐term check cultivars (currently between −20% and +15% of the mean of long‐term checks, “NC95” and “K326”). The unfavorable genetic association between cured leaf yields and alkaloid accumulation makes the development of higher yielding flue‐cured tobacco cultivars with acceptable alkaloid content difficult, and strong evidence exists for a yield plateau in United States flue‐cured tobacco since the mid‐1980's (Lewis, 2020).…”

Section: Introductionmentioning

confidence: 99%

Use of exotic Nicotiana tabacum germplasm for confronting an inverse genetic correlation in flue‐cured tobacco

Lewis

2023

Crop Science

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Inverse genetic correlations between cured leaf yields and alkaloid accumulation in flue‐cured tobacco (Nicotiana tabacum L.) complicate the development of higher yielding cultivars while maintaining alkaloids at commercially acceptable levels. Introgression of genomic regions from exotic source material that positively affect alkaloid levels, but with less of a corresponding negative influence on yielding ability, could enhance long‐term efforts to develop improved cultivars. Germplasm accessions “TI 464” and “TI 959” were previously identified as being potentially useful for this purpose. In this study, the relationships between yield and alkaloid accumulation were investigated in BC1F1 populations derived from crosses with these materials and found to be slightly negative or slightly positive. Derived BC1F2 families were used to calculate heritability estimates for alkaloid accumulation on a single plant basis that were low to intermediate in magnitude. The relationships between alkaloid levels of leaves from individual stalk positions and alkaloid levels averaged over all stalk positions were determined. The third stalk position was found to be the most predictive of average alkaloid levels. Selection for alkaloid levels using a single leaf from this stalk position could increase breeding efficiency. BC4F6 lines carrying low genomic contributions from either TI 464 or TI 959 were generated and evaluated as lines per se and in F1 hybrid combinations with a very high‐yielding inbred line with increased leaf number. Performance of these materials indicated that TI 464 and, to a lesser extent TI 959, may be useful for developing higher yielding tobacco cultivars with acceptable alkaloid levels.

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Nicotiana tabacum L.: Tobacco

Cited by 10 publications

References 111 publications

Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

Cow Urine Extract of Nicotiana tabacum Leaf Portends Hepatotoxicity in Male Wistar Rats

Use of exotic Nicotiana tabacum germplasm for confronting an inverse genetic correlation in flue‐cured tobacco

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