“…Peng Zhang, MD 1,2 , Wen-Yuan Li, MD 1 , Shi-Cheng Yang, MD 2 , Nai-Kuan Fu, MD 2 , Xiao-Gang Liu, MD 2 , Xue Zhang, MD 1 , Hong-Liang Cong, MD 2 , Wen-Hua Lin, MD 3 , Feng-Shi Tian, MD 4 , Cheng-Zhi Lu, MD 5 , and Jing Zhang, MD 2 Karanfil et al 1 comment on our article entitled "Preventive effects of nicorandil against contrast induced nephropathy in patients with moderate renal insufficiency undergoing percutaneous coronary intervention." 2 As described by Karanfil et al, 1 metformin has an adverse effect in the diabetic population after contrast agent exposure. 3 Patients with contrast-induced nephropathy (CIN) are at increased risk of long-term loss of renal function, cardiovascular events, and death, 4 as also highlighted by a Chinese expert consensus.…”