Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway

Deng, Qianqian; Wan, Qiyou; Liao, Juan; Fang, Derong; Wang, Linglu; Xiong, Shimin; Xu, Pei; Shen, Xubo; Li, Quan; Zhou, Yuanzhong

doi:10.1016/j.tiv.2022.105328

Cited by 7 publications

(5 citation statements)

References 48 publications

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“…54 The Akt signaling pathway plays a pivotal role in regulating various cellular processes, including cell invasion, apoptosis and migration and has attracted increasing attention for anti-cancer therapeutics. 55,56 Presently, we found that CCL3-CCR5 interaction could enhance the migratory and invasive capabilities of COAD cells by activating the Akt signaling pathway, which was consistent with previous studies. Furthermore, we examined whether CCL3 derived from dence has illustrated that MMPs such as MMP-2/9 were important markers for tumor metastasis.…”

Section: Discussionsupporting

confidence: 92%

“…Akt is a serine–threonine protein kinase which can be phosphorylated at Thr308 and Ser473 by PDK1 and mTORC2, respectively 54 . The Akt signaling pathway plays a pivotal role in regulating various cellular processes, including cell invasion, apoptosis and migration and has attracted increasing attention for anti‐cancer therapeutics 55,56 . Presently, we found that CCL3‐CCR5 interaction could enhance the migratory and invasive capabilities of COAD cells by activating the Akt signaling pathway, which was consistent with previous studies.…”

Section: Discussionsupporting

confidence: 89%

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CCL3‐CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway

Guan

Yao

et al. 2022

Environmental Toxicology

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Background Infiltration of tumor‐associated macrophages (TAMs) can promote tumorigenesis and development. C‐C motif chemokine ligand 3 (CCL3) was reported to be derived from TAMs and tumor cells and facilitate the progression of several cancers. Nevertheless, whether CCL3 can be derived from TAMs and tumor cells of colon adenocarcinoma (COAD) is unclarified. Methods Peripheral blood monocytes‐derived macrophages were polarized by the conditioned medium from COAD cells to establish TAM‐like macrophages (TAM1/2). RT‐qPCR and western blotting were used for detection of expression levels of CCL3 and its receptors C‐C motif chemokine receptor 1 (CCR1) and CCR5 in TAM1/2 and COAD cells. Immunofluorescence staining was utilized for evaluating CCL3, CD163 and CCR5 expression. The Akt signaling pathway‐associated protein levels were measured by western blotting. Transwell assays were used for assessing cell migration and invasiveness. Results CCL3 displayed a high level in TAMs and cancer cells of COAD. CCL3 activated the Akt signaling pathway by binding to CCR5. CCL3‐CCR5 axis facilitated COAD cell migration and invasiveness by activating the Akt signaling. CCL3 derived from both TAMs and cancer cells contributed to the malignant behaviors of COAD cells. High expression of CCL3/CCR5 was closely associated with poor prognoses of COAD patients. Conclusion CCL3‐CCR5 interaction promotes cell migration and invasiveness, and functions as a prognostic biomarker for COAD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

CCL3‐CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway

Guan

Yao

et al. 2022

Environmental Toxicology

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“…123 Stimulating human epidermal keratinocytes with 20 μg/mL (noncytotoxic dose) 124 or stimulating human monocytes with 30 μg/mL (noncytotoxic dose) CuO 125 can upregulate the expression of MMP2 and MMP9 and stimulate human villous trophoblast cell lines. Finally, stimulation with 100 μg/mL (cytotoxic dose) 126 can inhibit the expression of MMP2. However, the regulated pathways differed among these groups.…”

Section: Glycosaminoglycanmentioning

confidence: 99%

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix

Zhou,

Zhang,

Zeng

et al. 2024

ACS Nano

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Extracellular matrix (ECM) remodeling is accompanied by the continuous synthesis and degradation of the ECM components. This dynamic process plays an important role in guiding cell adhesion, migration, proliferation, and differentiation, as well as in tissue development, body repair, and maintenance of homeostasis. Nanomaterials, due to their photoelectric and catalytic properties and special structure, have garnered much attention in biomedical fields for use in processes such as tissue engineering and disease treatment. Nanomaterials can reshape the cell microenvironment by changing the synthesis and degradation of ECM-related proteins, thereby indirectly changing the behavior of the surrounding cells. This review focuses on the regulatory role of nanomaterials in the process of cell synthesis of different ECM-related proteins and extracellular protease. We discuss influencing factors and possible related mechanisms of nanomaterials in ECM remodeling, which may provide different insights into the design and development of nanomaterials for the treatment of ECM disorder-related diseases.

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“…30 Cytotoxic, genotoxic, and apoptotic effects of NiO NPs were also observed in human intestinal epithelial cells (Caco-2). 125 Moreover, Nicontaining NPs can also cause cytotoxicity in other types of cells including monocytes, [126][127][128] neutrophils, 129 lymphocytes, 130 RBCs, 131 endothelial progenitor cells, 132,133 endothelial cells, 134,135 spermatogonial cells (GC-1 spg), 136 trophoblasts (HTR-8/SVneo), 137,138 Sertoli-germ cells, 139 mesenchymal stem cells, 140 adipose stem cells, 141 pleural mesothelial 2 cells (NRM2), 142 kidney cells (NRK-52E), 143 skeletal myoblasts (L-6), 144 etc.…”

Section: Extra-pulmonary Effects Of Nicontaining Npsmentioning

confidence: 99%

The pulmonary effects of nickel-containing nanoparticles: cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms

Mo,

Zhang,

Zhang

2024

Environ. Sci.: Nano

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Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway

Cited by 7 publications

References 48 publications

CCL3‐CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway

CCL3‐CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix

The pulmonary effects of nickel-containing nanoparticles: cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms

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