Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin

Yu, Yanan; Guo, Meisong; Yuan, Mengwei; Liu, Weitong; Hu, Jingbo

doi:10.1016/j.bios.2015.09.036

Cited by 73 publications

(22 citation statements)

References 32 publications

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“…For this reason, different combinations of MWCNTs and different types of metal nanoparticles like silver nanoparticles [30], silica nanoparticles [8,12,31], ruthenium oxide nanoparticles [32], nickel nanoparticles (NiNPs) [33] and nickel oxide nanoparticles (NiONPs) have been studied [29]. Nickel based nanomaterials have become an intensively studied material not only because of their low cost in comparison with Ag, Co, Pd or Pt nanoparticles but also because they possess some desirable characteristics such as high electrical conductivity and good electrocatalytic activity [34].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Insulin Determination on NiNPs/chitosan‐ MWCNTs and NiONPs/chitosan‐MWCNTs Modified Pencil Graphite Electrode

et al. 2018

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The rising amount of patients suffering for diabetes mellitus increases the requirements for effective insulin sensors. Carbon materials are a suitable choice for the development of insulin sensors due to their electrochemical characteristics. Pencil graphite electrodes (PGE) represent the trade‐off between price and excellent conductive properties. The modification of PGE by NiO and Ni nanoparticles fixed by chitosan results in surface area enlargement and improved electrocatalytic properties. This paper is focused on the comparison of different properties of Ni and NiO nanoparticles and their effect on redox reaction mechanism of insulin and detection characteristics. The electrode modified by Ni nanoparticles displays linear range of 1 μM–5 μM (R2 0.80), limit of detection (LOD) of 4.34 μM and sensitivity of 0.12 μA/μM. On the other hand, the electrode modified by NiO nanoparticles displays enhanced electrochemical characteristics such as linear range of 0.05 μM–5 μM (R2 0.99), limit of detection of 260 nM and sensitivity of 0.64 μA/μM. These properties make the NiO nanoparticles modified PGE the appropriate candidate for insulin determination.

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Section: Introductionmentioning

confidence: 99%

Comparison of Insulin Determination on NiNPs/chitosan‐ MWCNTs and NiONPs/chitosan‐MWCNTs Modified Pencil Graphite Electrode

et al. 2018

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“…This increase is driven by a process where Ni(OH)2 reacts with hydroxyl ions to form NiOOH and the NiOOH reacts with insulin to produce oxidation currents. These reactions on the electrode surface indicate the Ni(II)/Ni(III) redox couple has a strong catalytic oxidation effect on insulin [18]. An increase in reduction peak currents was also observed in the cathode direction.…”

Section: Characteristics Of Spementioning

confidence: 77%

“…The behaviors of the Nickel hydroxide/SPE electrode oxidized in the insulin in 0.10 M NaOH solution were investigated using Amperometric i-t curves [18]. This i-t curve method reports a higher sensitivity than CV when the insulin concentration is low.…”

Section: G Amperometry Responsementioning

confidence: 99%

“…The oxidizability of insulin makes it easily detectable by using electrochemical methods. The difference between these methods mainly lies in the electrodes used, which, depending on the material and modification method, include carbon nanotube-nickel-cobalt oxide modified screen printed electrode [12], nickel nanoparticles [13] [14], silicon carbide nanoparticles [15], silica gel modified carbon paste electrode [16], nickel oxide nanoparticles-multiwalled carbon nanotubes [17], silica nanoparticles-Nafion modified electrode [11] and Nickel nanoparticle-modified electrode [18]. However, fabrication of these electrodes is an expensive and complex undertaking.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Detection of Insulin Based on Screen Printed Electrode Modified by Nickel Hydroxide

Zhang

Zhan

Zhao

et al. 2018

2018 IEEE 1st International Conference on Micro/Nano Sensors for AI, Healthcare, and Robotics (NSENS)

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This paper reports a novel electrochemical method for the detection of insulin in ultra-pure water. A screen printed electrode (SPE) modified by Nickel hydroxide was used as the working electrode, one with good activity of electro-catalytic oxidation-reduction for insulin. The SPE was modified by Nickel hydroxide using the electrodeposition method. The results showed that Nickel hydroxide was homogeneously electrodeposited on the surface of the working electrode. A coin-size electrolytic tank was fabricated with PDMS, which only requires 0.3ml of sample for the detection. The concentration of insulin was analyzed using the methods of Cyclic voltammetry (CV), Electrochemical impedance spectroscopy (EIS) and Chronoamperometry (i-t). The Nickel hydroxide used for detecting insulin showed good analytical characteristics, such as a high sensitivity of 14.797μA μM-1 , a good linear detection range of 100nM-5μM, and a low detection limit of 93nM. This nickel hydroxide modified SPE electrode has a much smaller size and is easier to fabricate than traditional electrodes, making it a much more promising candidate for an insulin sensor.

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“…By applying a modification, it is possible to achieve a significant improvement in the analytical characteristics of bare electrodes, such as a low detection limit, high sensitivity, and wide linear range [8]. Several publications for electrochemical insulin determination are based on electrode modifications using various metal nanoparticles (Ni, Zn, Cu, and Co) [12][13][14], metal oxide nanoparticles (NiO) [15], and carbon materials [1,16], or some combination of the above. Additionally, polymer membranes such as Nafion [8,17], chitosan [18], and polyethylene glycol [19] have been widely used to prevent the fast occupation of active sites by the chloride ions in body fluids.…”

Section: Introductionmentioning

confidence: 99%

NiO Nanoparticles for Electrochemical Insulin Detection

Shepa

Šišoláková

Vojtko

et al. 2021

Sensors

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Diabetes mellitus represents one of the most widespread diseases in civilization nowadays. Since the costs for treating and diagnosing of diabetes represent several billions of dollars per year, a cheap, fast, and simple sensor for diabetes diagnosis is needed. Electrochemical insulin sensors can be considered as a novel approach for diabetes diagnosis. In this study, carbon electrode with electrodeposited NiO nanoparticles was selected as a suitable electrode material for insulin determination. The morphology and surface composition were studied by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and X-ray photoelectron spectroscopy (XPS). For a better understanding of insulin determination on NiO-modified electrodes, the mechanism of electrochemical reaction and the kinetic parameters were studied. They were calculated from both voltammetric and amperometric measurements. The modified carbon electrode displayed a wide linear range from 600 nM to 10 µM, a low limit of detection of 19.6 nM, and a high sensitivity of 7.06 µA/µM. The electrodes were stable for 30 cycles and were able to detect insulin even in bovine blood serum. Additionally, the temperature stability of this electrode and its storage conditions were studied with appropriate outcomes. The above results show the high promise of this electrode for detecting insulin in clinical samples.

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Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin

Cited by 73 publications

References 32 publications

Comparison of Insulin Determination on NiNPs/chitosan‐ MWCNTs and NiONPs/chitosan‐MWCNTs Modified Pencil Graphite Electrode

Comparison of Insulin Determination on NiNPs/chitosan‐ MWCNTs and NiONPs/chitosan‐MWCNTs Modified Pencil Graphite Electrode

Electrochemical Detection of Insulin Based on Screen Printed Electrode Modified by Nickel Hydroxide

NiO Nanoparticles for Electrochemical Insulin Detection

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