Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission

Yin, Heng; Li, Xinglai; Wang, Chengbi; Li, Xiaocong; Liu, Jingbo

doi:10.1016/j.cbi.2024.110975

Cited by 1 publication

(1 citation statement)

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“…Nickel is an essential metal that can inhibit cytosine 5-methyltransferase activity in vivo and in vitro and elevate genomic DNA methylation in Chinese hamster cells even when DNA methyltransferase activity is depressed [47]. Nickel can induce mitochondrial damage [48] and autophagy through the Akt and APMK/mTOR pathways [49] in mouse kidney cells in vitro and in vivo. Treatments with nickel induced oxidative stress, DNA damage, and apoptosis in rat testes [50,51].…”

Section: Discussionmentioning

confidence: 99%

Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke

Jakubowski,

Sikora,

Bretes

et al. 2024

Life

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Objectives—Metallic elements and fibrin clot properties have been linked to stroke. We examined metallic and nonmetallic elements, fibrin clot lysis time (CLT), and maximum absorbance (Absmax) in relation to ischemic stroke. Design—A case–control study of ischemic stroke patients vs. healthy individuals. Subjects and Methods—Plasma and serum were collected from 260 ischemic stroke patients (45.0% women; age, 68 ± 12 years) and 291 healthy controls (59.7% women; age, 50 ± 17 years). Fibrin CLT and Absmax were measured using a validated turbidimetric assay. Serum elements were quantified by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). Data were analyzed by bivariate correlations and multiple or logistic regression. Results—In female stroke patients, copper, lithium, and aluminum were significantly lower compared with controls; in male stroke patients, potassium was lower, and beryllium was elevated. In female and male stroke patients, iron, zinc, nickel, calcium, magnesium, sodium, and silicon were significantly lower, while strontium was elevated. Positive correlations between fibrin clot properties and metals, observed in healthy controls, were lost in ischemic stroke patients. In multivariate regression analysis, fibrin CLT and/or Absmax was associated with zinc, calcium, potassium, beryllium, and silicon in stroke patients and with sodium, potassium, beryllium, and aluminum in controls. In logistic regression analysis, stroke was independently associated with lithium, nickel, beryllium, strontium, boron, and silicon and with sodium, potassium, calcium, and aluminum but not with fibrin CLT/Absmax. Conclusions—Various elements were associated with fibrin clot properties and the risk of ischemic stroke. Lithium, sodium, calcium, and aluminum abrogated the association of fibrin clot properties with ischemic stroke.

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