Nickel induces epithelial‐mesenchymal transition in pulmonary fibrosis in mice via activation of the oxidative stress‐mediated TGF‐β1/Smad signaling pathway
Shanchuan Cao,
Heng Yin,
Xinglai Li
et al.
Abstract:Nickel (Ni) is recognized as a carcinogenic metal, and its widespread use has led to severe environmental and health problems. Although the lung is among the main organs affected by Ni, the precise mechanisms behind this effect remain poorly understood. This study aimed to elucidate the physiological mechanisms underlying Ni‐induced pulmonary fibrosis (PF), using various techniques including histopathological detection, biochemical analysis, immunohistochemistry, western blotting, and quantitative real‐time PC… Show more
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