Intelligent computing tools such as artificial neural network and fuzzy logic are used as predictive modeling tools. The use of these methods, combined with model experimental results, may be an excellent predictive tool, allowing us to forecast the microstructure of the tested cast iron at the level of computer simulation. In this study, the reference training cases collected in one database were used to determine the parameters of the neuro-fuzzy ANFIS model. They mainly include the results of observations and measurements of the content of individual microstructural constituents of the compacted graphite iron, examined as a function of the content of individual alloy additives (molybdenum, nickel and copper introduced in various proportions). The training process of such a fuzzy inference system is done by constantly changing its parameters (parameters of the membership function) and determining new rule conclusions as a result of presenting individual case examples from the training sample. The conducted research has shown the possibility of applying the ANFIS model as a tool to control the chemical composition of compacted graphite iron in the production of castings with high-strength parameters.