Nickel(II) Complexes with Polyhydroxybenzaldehyde and O,N,S tridentate Thiosemicarbazone ligands: Synthesis, Cytotoxicity, Antimalarial Activity, and Molecular Docking Studies

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

“…Further, molecular docking has helped to understand their site of action suggesting that they bind to the minor grooves and interact with DNA base pairs involving benzaldehyde, triphenylphosphine, aliphatic chain and phenyl moieties. [103] Theeramunkong et al synthesized the isoquinoline derivative (89) and studied the anti-malarial activity against PfK1 and Pf3D7 strains (IC 50 of 1.91 and 2.31 μM, respectively). [104] Deferiprone-resveratrol hybrids (90) were reported by Maneekesorn et al with IC 50 of 16.82 and 47.67 μM against Pf3D7 and PfK1 strain with superior anti-plasmodial potential and lipophilicity than parent scaffold, deferiprone.…”

Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

“…Mixed complexation was established when an ethanolic solution of thiosemicarbazone ligand 66a – d was added to nickel(II)chloride hexahydrate and PPh 3 and then the mixture was refluxed for 6 h to produce tetradentate Ni(II) thiosemicarbazone complexes 67a – d in 63–71% as illustrated in Scheme 33 [ 88 ]. The complexes were further characterized with single crystal X-ray diffraction.…”

“…Complexes 67b and 67c showed moderate in vitro antimalarial activity with IC 50 9.88 ± 0.23 and 1.06 ± 0.01 μM, respectively. Remarkably, the antimalarial activity increases as the hydrophobicity of the substituent group attached at the N(3) position increases [ 88 ].…”

Perchlorate-induced structural diversity in thiosemicarbazone copper(ii) complexes provides insights to understand the reactivity in acidic and basic media

“…Thiosemicarbazones (TSCs) and their metal complexes have been proposed to exhibit a wide range of biological activities [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] and tested as drugs against microbial diseases (malaria, [16][17][18] tuberculosis, 19,20 smallpox, 21,22 influenza, 23 leishmaniasis 24,25 ), neurological pathologies (Alzheimer's, [26][27][28][29] Parkinson's 30 ) and cancer. [31][32][33][34][35] Several biochemical targets have been identified, [36][37][38][39][40][41][42][43] while the formation of TSC-Fe and TSC-Cu complexes seems to play an important role in their affectation to cells.…”