Nickel(II) based homo- vs heterometallic 1D coordination polymers derived from a novel 6-aminouracil building block: Structures, topologies, non-covalent interactions, magnetism, and antibacterial activity

Purkayastha, Atanu; Debnath, Diptanu; Majumder, Moumita; Ortega‐Castro, Joaquín; Kirillov, Alexander M.; Ganguly, Rakesh; Kłak, Julia; Frontera, Antonio; Misra, Tarun Kumar

doi:10.1016/j.ica.2018.06.037

Cited by 11 publications

(3 citation statements)

References 67 publications

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“…Secondly, the ligand also destroys part of the bacterial membrane, and the bacteria cannot further divide and multiply and thus die. These observations are similar to the biological activities of previously successfully reported complexes [76][77][78][79].…”

Section: Antibacterial Activitiessupporting

confidence: 90%

A Newly Synthesized Heterobimetallic NiII-GdIII Salamo-BDC-Based Coordination Polymer: Structural Characterization, DFT Calculation, Fluorescent and Antibacterial Properties

et al. 2019

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A unprecedented hetero-bimetallic 3d-4f BDC-salamo-based coordination polymer, [(L)Ni(BDC)Gd(NO3)(DMF)] was prepared and validated via elemental analyses, IR and UV–Visible absorption spectra, DFT calculation, and X-ray crystallography. The six-coordinated Ni1 ion lies at the N2O2 donor site of the L2− moiety, and one DMF O atom and carboxylate O atom occupy, collectively, the axial positions, and form a twisted octahedron. The nine-coordinated Gd1 ion consists of three oxygen atoms (O12, O13, and O14) of two carboxylate groups, two oxygen atoms (O8 and O9) derived from one bidentate nitrate group, and an O2O2 coordination site (O1, O2, O6, and O5) of the L2− unit, forming a twisted three-capped triangular prism coordination geometry. Compared to the ligand (H2L), the fluorescence intensity decreases due to the coordination of metal ions. Meanwhile, the antibacterial activities are researched.

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Section: Antibacterial Activitiessupporting

confidence: 90%

A Newly Synthesized Heterobimetallic NiII-GdIII Salamo-BDC-Based Coordination Polymer: Structural Characterization, DFT Calculation, Fluorescent and Antibacterial Properties

et al. 2019

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“…For the hemocompatibility study in concentration-dependent kinetics, the murine lymphocytes and monocytes are incubated with varying concentrations (1–20 mg mL –1 ) of L11P for 24 h for the viability assay . A hemolysis assay is performed following a standard protocol reported earlier …”

Section: Experimental Sectionmentioning

confidence: 99%

“…49 A hemolysis assay is performed following a standard protocol reported earlier. 46 Measurement of Apoptosis by Fluorescence Microscopy. The effect of L11P on induction apoptosis in DL cells is measured by exposure of phosphatidyl serine (PS) with Annexin V-FITC/PI using fluorescence microscopy.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Azouracil and Its Cu(II)-Catalyzed Cyclization to an Anticancer Active Triazole Derivative: Symmetrical and Asymmetrical Reductive Cleavage, DNA Interaction, and Molecular Docking Studies

Banerjee

Ghosh

Pradhan

et al. 2019

ACS Appl. Bio Mater.

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The 6-amino-1,3-dimethyl uracil-based azo derivative (p-carboxy phenylazouracil, L11) undergoes Cu(II)-catalyzed cyclization to a triazole derivative, namely, 1,3-dimethyl-8-(p-carboxy phenyl) azapurine (L11P). Interestingly, the azo functionality of L11 undergoes both symmetrical and asymmetrical reductive cleavage at two different reaction conditions. The chloride salts of Mn(II), Ni(II), and Pd(II) catalyze reductive cleavage of an azo moiety in an asymmetric manner, producing a new uracil hydrazine derivative (A3). On the other hand, hydrazine catalyzes symmetrical reductive cleavage of the azo moiety of L11, resulting in 5,6-diamino-1,3-dimethyl uracil (A2) along with the starting p-aminobenzoic acid (A1). Time-dependent density functional theoretical (TD-DFT) studies provide optimized geometries of L11, L11P, and A3 along with their orbital energies. The L11 and L11P bind firmly to genomic DNA of E. coli with a site size n ∼ 9 and n ∼ 8. The L11P shows anticancer activity on selected murine lymphoma cancer cell lines (DL, YAC1, and 2PK3). In addition, its antiproliferative activity is measured with several cancer cell lines and found hemocompatible toward blood cells. Corresponding molecular docking studies of L11P with caspase-3 (cysteine-aspartic proteases) unlock their mode of interaction.

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Copper(II) complexes of 1,3-dimethyl-5-(4′/3′-pyridylazo)-6-aminouracil: Structures, redox, magnetic and protein binding properties

Nandi

Purkayastha

Kłak

et al. 2022

Journal of Molecular Structure

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Nickel(II) based homo- vs heterometallic 1D coordination polymers derived from a novel 6-aminouracil building block: Structures, topologies, non-covalent interactions, magnetism, and antibacterial activity

Cited by 11 publications

References 67 publications

A Newly Synthesized Heterobimetallic NiII-GdIII Salamo-BDC-Based Coordination Polymer: Structural Characterization, DFT Calculation, Fluorescent and Antibacterial Properties

A Newly Synthesized Heterobimetallic NiII-GdIII Salamo-BDC-Based Coordination Polymer: Structural Characterization, DFT Calculation, Fluorescent and Antibacterial Properties

Azouracil and Its Cu(II)-Catalyzed Cyclization to an Anticancer Active Triazole Derivative: Symmetrical and Asymmetrical Reductive Cleavage, DNA Interaction, and Molecular Docking Studies

Copper(II) complexes of 1,3-dimethyl-5-(4′/3′-pyridylazo)-6-aminouracil: Structures, redox, magnetic and protein binding properties

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