Nickel dermatitis hazards from prostheses.

Samitz, M. H.; Katz, Simon

doi:10.1111/j.1365-2133.1975.tb03078.x

Cited by 77 publications

(12 citation statements)

References 16 publications

(2 reference statements)

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“…Vitallium is mainly made up of cobalt and chromium but also contains some nickel. The stainless steel used in prostheses normally contains nickel in a concentration of 8.5-14% but this can be as high as 35% (3)(4)(5). Stainless steel also contains chromium (e.g., 20%), with small amounts of manganese, and molybdenum and less than I% of carbon, nitrogen, silicon, niobium, sulphur and phosphorus.…”

Section: Metal Composition Of Implantsmentioning

confidence: 99%

Nickel sensitivity and the implantation of orthopaedic prostheses

Gawkrodger

1993

Contact Dermatitis

109

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There is no evidence that nickel-sensitive patients, when given a modern plastic-to-stainless-steel hip replacement, develop cutaneous reactions or loosening of their prostheses. However, eczema is occasionally seen with static metal prostheses and eruptions sometimes accompanied the use of the older types of joint prosthesis. Modern plastic-to-metal joint replacements rarely cause sensitization to the composite metals. In the rare instances when this has been detected by patch testing, the affected patients have not developed eczema or loosening of their prostheses.

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Section: Metal Composition Of Implantsmentioning

confidence: 99%

Nickel sensitivity and the implantation of orthopaedic prostheses

Gawkrodger

1993

Contact Dermatitis

109

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“…We tested this hypothesis by quantitatively evaluating the local inflammatory responses of spinal implant CoCr-alloy particles and nickel (Ni) particles in an in vivo rabbit model with perioperative and postmortem radiographic, histologic, and quantitative immunocytochemical analyses. Nickel was chosen as a positive control because while known to be reactive [3,19,26,31,34,37], it is also orthopedically relevant as minor component of CoCr-alloy and steel implant alloys.…”

Section: Introductionmentioning

confidence: 99%

Quantifying subtle but persistent peri-spine inflammation in vivo to submicron cobalt–chromium alloy particles

2012

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Purpose We evaluated the consequences of cobaltchromium alloy (CoCr) wear debris challenge in the perispine region to determine the inflammation and toxicity associated with submicron particulates of CoCr-alloy and nickel on the peri-spine. Methods The lumbar epidural spaces of (n = 50) New Zealand white rabbits were challenged with: 2.5 mg CoCr, 5.0 mg CoCr, 10.0 mg CoCr, a positive control (20.0 mg of nickel) and a negative control (ISOVUE-M-300). The CoCr-alloy and Ni particles had a mean diameter of 0.2 and 0.6 lm, respectively. Five rabbits per dose group were studied at 12 and 24 weeks. Local and distant tissues were analyzed histologically and quantitatively analyzed immunohistochemically (TNF-a and IL-6). Results Histologically, wear particles were observed in all animals. There was no evidence of toxicity or local irritation noted during macroscopic observations in any CoCr-dosed animals. However, Ni-treated control animals experienced bilateral hind leg paralysis and were euthanized at Day 2. Histopathology of the Ni particle-treated group revealed severe neuropathy. Quantitative immunohistochemistry demonstrated a CoCr-alloy dose-dependent increase in cytokines (IL-6, TNF-a, p \ 0.05) at 12 and 24 weeks. Conclusions Subtle peri-spine inflammation associated with CoCr-alloy implant particles was dose dependent and persistent. Neuropathy can be induced by highly reactive Ni particles. This suggests peri-spine challenge with CoCralloy implant debris (e.g., TDA) is consistent with past reports using titanium alloy particles, i.e., mild persistent inflammation.

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“…The mechanism by which these reactions to prostheses occur is not clear. Type I, III and IV allergies have been implicated (13), enhanced by local factors (14). In our patient, a type III and/or IV hypersensitivity is suggested, triggered by nickel released by chewing, probably modulated by ingestion during meals.…”

Section: Discussionmentioning

confidence: 56%

Contact stomatitis from a dental prosthesis

Romaguera¹,

Vilaplana²,

Grimalt³

1989

Contact Dermatitis

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Key words: allergic contact stomatitis; metal dental prosthesis; nickel.18 months ago, after having a metal dental prosthesis fitted, a 40-year-old female, with a history of intolerance to metals since infancy, developed persistent gingivostomatitis and ulceration; this disappeared after removal of the prosthesis.Patch tests showed positivity to nickel in the GEIDC standard series ( + + ); all other tests were negative. A special series (Chemotechnique) for dental screening (21 allergens) also showed positivity only to nickel. The metal dental prosthesis was made of metal alloy and porcelain, and made by Ordenta under the

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Nickel dermatitis hazards from prostheses.

Abstract: This report reviews data relating to the nickel hazard from implanted prostheses. It is shown that nickel is released from stainless steel prostheses by the action of sweat, blood and physiological saline solution. In laboratory animals, solubilized nickel isn the tissue near the implant.

Cited by 77 publications

References 16 publications

Nickel sensitivity and the implantation of orthopaedic prostheses

Nickel sensitivity and the implantation of orthopaedic prostheses

Quantifying subtle but persistent peri-spine inflammation in vivo to submicron cobalt–chromium alloy particles

Contact stomatitis from a dental prosthesis

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