Nickel-Containing Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase^,

The rocky roots of the acetyl-CoA pathway

“…nickel in a novel Ni-Ni-[4Fe4S] cluster [18]. CODH and ACS can occur together as a single bifunctional enzyme (ACS -CODH) or as separate, monofunctional enzymes [19,20].…”

“…The structures of a C-cluster in CODH and of the A-cluster of ACS (Figure 2a [16][17][18][19][20]35]. The exact reaction mechanism for ACS has not been resolved: differing proposals have been put forth [17,20] and differences have been also reported regarding the presence of copper, zinc and nickel at the active site of the A cluster [17,20,35]; nickel has been found at the active site of the active enzyme [18].…”

Synthesis of MFe3S4Clusters Containing a Planar MIISite (M = Ni, Pd, Pt), a Structural Element in the C-Cluster of Carbon Monoxide Dehydrogenase

“…The NiFe 3 S 4 portion of the product cluster is cubanoid inasmuch as the axial Ni···S* separations in independent clusters are 2.60-2.90 Å. 16 (1) While the product cluster of reaction 1 lacks the exo iron atom and contains a non-physiological ligand, it resembles a C-cluster by the integration of planar Ni II , with an accompanying long Ni···S* distance, into a NiFe 3 S 4 unit. This unit, with planar Ni II in the best defined case, is a constant structural component of C-clusters.…”

Oxidation of 3,5-di-tert-butylcatechol in the presence of V-polyoxometalate

“…Metal-containing redox enzymes are ubiquitous in nature and many can perform such functions under mild conditions (Sigel & Pyle, 2007;Cowan, 1998;Ragsdale & Kumar, 1996). Catechol oxidase and catechol dioxygenases are two important enzymes in these investigations.…”