Nickel complexes of some thiosemicarbazones: Synthesis, structure, catalytic properties and cytotoxicity studies

The Effect of C‐2 Substituents of Salicylaldehyde‐Based Thiosemicarbazones on the Synthesis, Spectroscopy, Structures, and Fluorescence of Nickel(II) Complexes

“…Previously, we reported the Type IV mode in one dinuclear Cu II complex [Cu 2 L 2 (bipy)] (R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = Et) with a 5,4‐coordination pair 44. Mono(thiosemicarbazones) with Ni II /Cu II ions in the presence of 2,2′‐bipyridine, 4,4′‐biyridine, or terpyridyl auxiliary ligands have yielded a dinuclear complex [Ni 2 L 2 (bipy)]7b with a 6,4‐coordination pair (R 1 = 2‐HO‐C 6 H 4 , R 2 = CH 3 , R 3 = H), 4,4′‐biyridyl‐bridged dinuclear complexes [M 2 L 2 (μ‐4,4′‐bipy)] (M = Ni, Cu, L is an O , N , S ‐chelating dianion; R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = H, Ph, 4‐MeOC 6 H 4 ),7a,7c,7d,8 or an octahedral [NiL(terpy)] complex (R 1 = 2‐HO‐C 6 H 4 , R 2 = H, R 3 = H, terpy = terpyridine) 7b. The [Ni 2 L 2 (bipy)] complex does not have N‐2 bridges; instead one O and one S atom act as a heterobridge between two Ni metal centers with a central Ni(μ‐O,S‐L)Ni core 7b.…”

“…There are a few Ni II complexes of thiosemicarbazones with bipyridines as coligands 7,8. For example, 4,4′‐bipyridine (4,4′‐bipy) has formed bridged dinuclear Ni II complexes, [(NiL) 2 (μ‐4,4′‐bipy)] (R 1 = H, R 2 = H, R 3 = H, C 6 H 5 , 4‐MeOC 6 H 4 , Scheme ),7a,7c,7d,8 and there is only one structurally characterized dinuclear complex with 2,2′‐bipyridine (bipy), namely, [Ni 2 L 2 (bipy)] (R 1 = H, R 2 = CH 3 , R 3 = H), which has one six‐coordinate Ni center and one four‐coordinate Ni center (6:4‐coordinate) 7b. We have used a series of thiosemicarbazone ligands (shown in Scheme ) and bipyridine coligands [bipy, 4,4′‐dimethyl‐2,2′‐bipyridine (dmbipy), 4,4′‐bipy) to interact with Ni II ions.…”

Ni(ii) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines

“…The electrophoretic pattern suggests that changes in conformations of the plasmid were caused by the binding of 1, and retardation of the migration of DNA through the gel is observed for molecules which bind covalently to DNA. [93][94][95] Evaluation of anticancer activity Nickel hydrazone complexes have been extensively investigated for anticancer properties [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] but in general, the literature data deals with their activity described by IC 50 concentrations with data obtained by mean of colorimetric assays. Such methodology provides only the information on how the applied compound reduces number of viable cells in the treated population with regard to non-treated control for a specic time of incubation, therefore, calculated IC 50 value gives an indication on antiproliferative activity of investigated treatment, but not on how the treatment affected cell proliferation: by triggering apoptotic or necrotic cell death, due to prolongation of mitotic cycle with delayed population growth, or by induction of cell dormancy.…”

“…[12][13][14] Hydrazone complexes of Ni exhibit a wide spectrum of biological activity, 11 and a number of these complexes have shown higher anti-cancer activity than the drugs approved for treatment of certain types of cancer. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Ni(II) ion has d 8 electronic conguration, same as Pt(II)the metal ion in, so far, all of the approved anti-cancer treatment drugs: cisplatin (CDDP), carboplatin, oxaliplatin, nedaplatin, and lobaplatin. 30 Unlike Pt(II), which only exhibits square-planar geometry (coordination number four), Ni(II) oen exhibits higher coordination numbers, offering greater variation in geometry.…”

Carbamohydrazonothioate derivative—experimental and theoretical explorations of the crystal and molecular structure

“…They combine mixed hard-soft donor character and versatile coordination ability [4,5], which are determined by the structure of a particular compound. Numerous metal complexes of various thiosemicarbazones have been investigated [4][5][6][7][8][9][10][11][12][13][14]. A significant attention has been drawn to their medicinal applications.…”