Nickel-Catalyzed Hydrocarboxylation of Terminal Unactivated Alkenes: Formation of Branched Carboxylic Acids and Competing Catalyst Deactivation from CO2 Reduction to CO
Fatemeh Khamespanah,
James B. Gerken,
David S. Mannel
et al.
Abstract:The reductive coupling of CO 2 and alkenes represents a compelling strategy for the synthesis of carboxylic acids. In this study, we show that Ni(OAc) 2 and 6,6′-Me 2 bpy (dmbpy) catalyze hydrocarboxylation of terminal unactivated alkenes to afford the branched 2-methyl-substituted carboxylic acids. The nickel/dmbpy speciation in solution is elucidated through electrochemical and UV−visible and NMR spectroscopic methods. A catalyst deactivation process is identified, involving competitive reduction of CO 2 to … Show more
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