Nickel‐Catalyzed Enantioselective Synthesis of Dienyl Sulfoxide
Li Gao,
Yin‐Qi Wang,
Ya‐Qian Zhang
et al.
Abstract:Sulfoxides are widely used in the pharmaceutical industry and as ligands in asymmetric catalysis. However, the efficient asymmetric synthesis of this structural motif remains limited. In this study, we disclosed a Ni‐catalyzed enantioconvergent reaction that utilizes both racemic allenyl carbonates and β‐sulfinyl esters. Our method employs cheap and more sustainable Ni(II) as a precatalyst and successfully overcomes the challenging poisoning effect and instability of sulfenate generated in situ. This enables t… Show more
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