Nickel-catalyzed asymmetric hydrogenation for the preparation of α-substituted propionic acids
Bowen Li,
Zhiling Wang,
Yicong Luo
et al.
Abstract:Transition metal-catalyzed asymmetric hydrogenation is one of the most efficient methods for the preparation of chiral α-substituted propionic acids. However, research on this method, employing cleaner earth-abundant metal catalysts, is still insufficient in both academic and industrial contexts. Herein, we report an efficient nickel-catalyzed asymmetric hydrogenation of α-substituted acrylic acids affording the corresponding chiral α-substituted propionic acids with up to 99.4% ee (enantiomeric excess) and 10… Show more
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