Nickel Absorption and Kinetics in Human Volunteers

Fw, Sunderman; Hopfer, Sidney M.; Kr, Sweeney; Ah, Marcus; Bm, Most; Creason, John P.

doi:10.3181/00379727-191-42881

Cited by 124 publications

(119 citation statements)

References 15 publications

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“…Food intake and gastric emptying are of substantial significance for the bioavailability of nickel from aqueous solutions. The absorption of free nickel ions released in the gastrointestinal tract may be 40 times higher than that of complex-bound nickel from foodstuff (Sunderman et al, 1989). The absorption of nickel from drinking water is increased by fasting (Nielsen et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Some Heavy Metals in Imported Chocolate and Candies Sold in Nigeria

Ochu¹,

Uzairu²,

Kagbu³

et al. 2012

JFR

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This study was initiated as a follow-up information on some impounded products chocolates and candies (Samples A, B, C and D) imported from overseas, and sold in Nigeria markets. This result as their failure to meets Nation Agency for food drug administration and control (NAFDAC) regulatory standard. Samples of these products were collected in five markets of each six states each from the six geographical zones: North-West (Bauchi), North-East (Kano), North-Central (Kogi), South-West (Lagos), South-East (Abia), and South-South (Rivers) of the country. In order to evaluate the quality of the products, the levels of some heavy metals (Cu, Mn, Fe, Ni, Zn, Ti and Cr) were evaluated in the samples using X-ray fluorescence (XRF). Concentrations of metals in both chocolates and candies ranged 3.0 -4.2 mg/g for Cu, 40.0 -55.7 mg/g for Mn, ND -102.5 mg/g for Fe, ND -305.0 mg/g for Ni, ND -42.5 mg/g for Zn, ND -23.8 mg/g for Ti, and ND -10.8 mg/g for Cr. The results showed that that these metals are at higher levels in Samples A, B, C and D compared to other studies in candies and chocolates in Nigeria. Correlation analysis among metals revealed positive correlations, which indicates similar sources of these metals. Also, evaluation of dietary intake of these products daily revealed that Samples A (except for Cu), B and C are above the daily dietary recommended limit for all the studied metals in food. Thus a frequent intake of these contaminated products is likely to induce health effects arising largely from Cu, Mn, Fe, Ni and Zn.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Some Heavy Metals in Imported Chocolate and Candies Sold in Nigeria

Ochu¹,

Uzairu²,

Kagbu³

et al. 2012

JFR

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“…Finally, the absorption of Ni via drinking water was also studied in the presence of disodium ethylenediaminetetraacetic acid (Na 2 EDTA) to the diet decreased the plasma Ni levels below those observed in non-exposed subjects under fasting conditions, showing a lower bioavailability of Ni complexes in comparison to free Ni. Sunderman et al (1989) studied the absorption of Ni in 10 human volunteers (six males and four females, ages 22-55 years). In a first experiment, study individuals were given 12-50 µg Ni/kg b.w.…”

Section: Humansmentioning

confidence: 99%

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Publication¹

2015

EFS2

116

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EFSA received a request from the Hellenic Food Authority (EFET) for a scientific opinion on the risk to human health from the presence of nickel (Ni) in food, particularly in vegetables. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) decided to extend the risk assessment also to drinking water. The reproductive and developmental toxicity in experimental animals was selected as the critical effect for the assessment of chronic effects of Ni. A tolerable daily intake of 2.8 µg Ni/kg body weight (b.w.) per day was derived from a lower 95 % confidence limit for a benchmark dose at 10 % extra risk (BMDL 10 ) of 0.28 mg/kg b.w. for post-implantation fetal loss in rats. The current dietary exposure to Ni raises concern when considering the mean and 95th percentile chronic exposure levels for all different age groups. The systemic contact dermatitis (SCD) elicited in Ni-sensitive humans after oral exposure to Ni was selected as the critical effect suitable for the assessment of acute effects of Ni. A lowest BMDL 10 of 1.1 µg Ni/kg b.w. was derived for the incidence of SCD following oral exposure to Ni of human volunteers. The CONTAM Panel applied a margin of exposure (MOE) approach and considered an MOE of 10 to be indicative of a low health concern. The MOEs calculated considering the estimated mean and the 95th percentile acute exposure levels were considerably below 10 for all age groups. Overall, the CONTAM Panel concluded that, at the current levels of acute dietary exposure to Ni, there is a concern that Ni-sensitized individuals may develop eczematous flare-up skin reactions. The CONTAM Panel noted the need for mechanistic studies to assess the human relevance of the effects on reproduction and development observed in experimental animals and for additional studies on human absorption of nickel from food, for example in combination with duplicate diet studies. Following a call for data on Ni levels in food and drinking water (water intended for human consumption and mineral waters), a total of 18 885 food samples and 25 700 drinking water samples were available in the final dataset to estimate dietary exposure to nickel. No speciation data were provided. Samples were collected between 2003 and 2012 in 15 different European countries, with almost 80 % of the total collected in one Member State. The most reported analytical methods were inductively coupled plasma-mass spectrometry (ICP-MS) and atomic absorption spectrometry (AAS), that represented 54 % and 42 % of the methods reported, respectively. The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS). In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery'. In the final dataset, left-censored data represented 66 % of the analytical results, with 35 % in food samples and 89 % in drinking water sa...

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“…H. pylori requires efficient acquisition of nickel, as this is the metal cofactor of the essential colonization factors urease and hydrogenase. Nickel availability in human serum is very low (2 to 11 nM), and the nickel concentration in ingested food varies significantly depending on the diet and on food sources (91,608). One certain and several potential nickel transporters have been identified in H. pylori.…”

Section: Microbiology Of H Pylorimentioning

confidence: 99%

Pathogenesis ofHelicobacter pyloriInfection

2006

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SUMMARY Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay between the host and the bacterium. Host immune gene polymorphisms and gastric acid secretion largely determine the bacterium's ability to colonize a specific gastric niche. Bacterial virulence factors such as the cytotoxin-associated gene pathogenicity island-encoded protein CagA and the vacuolating cytotoxin VacA aid in this colonization of the gastric mucosa and subsequently seem to modulate the host's immune system. This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori.

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Nickel Absorption and Kinetics in Human Volunteers

Cited by 124 publications

References 15 publications

Evaluation of Some Heavy Metals in Imported Chocolate and Candies Sold in Nigeria

Evaluation of Some Heavy Metals in Imported Chocolate and Candies Sold in Nigeria

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Pathogenesis ofHelicobacter pyloriInfection

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