Nichtschilddrüsenstoffe mit Schilddrüsenwirkung

Abelin, I.; Neftel, A.

doi:10.1007/bf01861207

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…Considerable success in the concentration and purification of the thyroidal principle contained in certain iodinated proteins was reported by Abelin and his co-workers (17)(18)(19)(20)(21). When iodinated proteins were first hydrolyzed with alkali, an acid-insoluble precipitate was obtained which contained about 26 per cent iodine and was designated as homo-thyroxine.…”

Section: Historical Backgroundmentioning

confidence: 96%

Thyroidal Action of Synthetic Thyroprotein

Reineke¹,

Turner²

1943

The Journal of Clinical Endocrinology & Metabolism

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Section: Historical Backgroundmentioning

confidence: 96%

Thyroidal Action of Synthetic Thyroprotein

Reineke¹,

Turner²

1943

The Journal of Clinical Endocrinology & Metabolism

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“…One of the most striking developments of the past few years in regard to thyroid physiology was the demonstration by Ludwig & von Mutzenbecher (85) since confirmed (2,55), that the iodination of casein gave rise to a material exhibiting the physiologic activity of the thyroid hormone. Hydrolysis of the treated protein yielded thyroxin.…”

Section: The Thyroidmentioning

confidence: 98%

Metabolic Functions of the Endocrine Glands

Soskin¹

1941

Annu. Rev. Physiol.

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This attempt at a brief review of the contributions of the past year to our knowledge of the metabolic functions of the endocrine glands must of necessity be selective rather than all-inclusive. This is not only because of the number of papers which have appeared, but also because many of the findings cannot yet be related to the pre-existing knowledge. For these reasons it has seemed desirable to limit the present discussion to the most pertinent literature concerning the influence of the pancreas, the adrenal cortex, the thyroid and the anterior hypophysis on the metabolism of carbo hydrates, fats, and proteins respectively.Since it is possible to make only the briefest mention of the related work which appeared before the period under considera tion, the reader is referred to certain review articles published during this time. Van Dyke's second volume on the pituitary gland (144) covers the international literature on the subject from 1935 to 1938. Collip (28) has discussed the significance of the various active fractions of anterior pituitary extracts. The influence of the pituitary gland on carbohydrate metabolism has been re viewed by Young (154) , and of the adrenal cortex by Long and associates (83). Raab (110) has considered the relation of the hor mones to fat metabolism.It is understood that the interpretation of new observations will often depend upon one's previous conception of the funda mentals of the subject. The writer has recently summarized some of his views on carbohydrate metabolism (126, 127). THE PANCREAS A more complete understanding of the influence of other hor mones on carbohydrate metabolism still awaits final agreement as 1 Th e help of Dr. R. Levine in the collection of the material for t " his review is gratefully acknowledged.543 Annu. Rev. Physiol. 1941.3:543-572. Downloaded from www.annualreviews.org Access provided by New York University -Bobst Library on 02/08/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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“…The essential changes in the revised method for ranges> 10 yg. N have proceeded from Abelin's [1938] use of boric acid as absorbent (also studied by Kawerau [1941]). The reduction in concentration of the boric acid in the absorbent, or the substitution of half-saturated MgCl2, with the use of a new indicator more suitable for this particular titration from the alkaline to the acid side, make the end point much more satisfactory.…”

Section: Estimation Of Nh3 and Ureamentioning

confidence: 99%

“…In the new method for urine and blood urea, as also urine NH3 or NH3 in quantities greater than about 10 jg. NH3-N, there is used the principle introduced into the microdiffusion technique by Abelin [1938], and further studied by Kawerau [1941], of absorbing the NH3 into a solution such as dilute boric acid and titrating back with standard HCI. Improvements are included arising out of a further study of the conditions of the microdiffusion procedure, an account of which is given at the outset.…”

mentioning

confidence: 99%

“…The boric acid procedure of Abelin [1938] was criticized by one of us [Conway, 1939] as giving a poor end point with the Tashiro indicator compared with the barium hydroxide titration, but it was noted that the principle was certainly a good one and that a change E. J. CONWAY AND E. O'MALLEY in conditions might make it very suitable. This requisite change is described below; it includes the use of an indicator which is more suitable for the purpose, since it changes at an end point where the buffering is minimal and it is more sensitive than the Tashiro indicator when titrating in the alkaline to acid direction; also by a reduction in the strength of the boric acid absorbent (or the use of half-saturated MgC12) combined with potassium metaborate as alkali.…”

mentioning

confidence: 99%

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Microdiffusion methods. Ammonia and urea using buffered absorbents (revised methods for ranges greater than 10μg. N)

Conway

O’Malley

1942

Biochemical Journal

406

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Microdiffusion methods for determinations of minute amounts of ammonia, urea, carbon dioxide, the halogens etc., are now established in many laboratories. A general account of apparatus and several applications have been given elsewhere [Conway, 1939]. Recent extensions include submicro-determinations of total N by Needham & Boell [1939], as well as a further very accurate submicro-total N method by Tompkins & Kirk [1942], also amideand nitrate-N etc. by Borsook & IDubnoff [1939], quantitative acetone determination by Werch [1940] and an accurate acetone method using bisulphite absorption by Winnick [1941; 1942], who has also extended the technique to lactic acid and threonine estimations. As shown elsewhere micro-NH3 determinations by the microdiffusion technique can be brought to any desirable level of accuracy. Recoveries are better than with aeration methods, the apparatus required,is simpler and large numbers of determinations can be carried out in one series. Using the standard unit and 0-2 ml. of the NH3-containing fluid the full absorption time at room temperature is 45 min., but with rocking this can be reduced to 10 min. Such times arise out of the principles discussed and the experimental results described. (Borsook & Dubnoff [1939] have erred in claiming an absorption time of 90 min. as an advance on the microdiffusion technique.) The present study is directed especially to the removal of certain objections to the clinical use of the microdiffusion method for urea, but has also a more general application for concentrations of NH3 beyond a certain level. The blood urea method as originally described [Conway, 1933] had the disadvantage for clinical use, as commented on by Lee & Widdowson [1937], that the upper limit was 100 mg. urea/100 ml. Occasional blood ureas exceed this figure, though as pointed out

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Nichtschilddrüsenstoffe mit Schilddrüsenwirkung

Cited by 9 publications

References 5 publications

Thyroidal Action of Synthetic Thyroprotein

Thyroidal Action of Synthetic Thyroprotein

Metabolic Functions of the Endocrine Glands

Microdiffusion methods. Ammonia and urea using buffered absorbents (revised methods for ranges greater than 10μg. N)

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