Nichtionische iodierte dimere versus monomere Röntgenkontrastmittel: Effekte auf Komplementfaktoren in vivo

Abstract

The presented data shows different influences of CM injection on the analyzed complement factors after 5 min. that were commonly no longer present 30 min. after CM injection. The dimeric iotrolan induced a significantly increased frequency of unwanted CM reactions than the monomeric iopromide. The question of whether iotrolan is possibly able to activate the classic way of the complement cascade should be analyzed in the future in a greater patient group.

Contrast Medium-Induced Leukopenia

“…Moreover, in a patient with clinical anaphylaxis the leukocytes remained unchanged [3] . Since ICMs are not cytotoxic, other mechanisms such as cell destruction by complement activation [4] and/or apoptosis [5] should be discussed as responsible for the observed leukopenia.…”