Nichtinvasiver Funktionstest zur Überprüfung der Gefäßreagibilität in der Schwangerschaft und bei schwangerschaftsinduzierter Hypertension (SIH)

Abstract

At present, there is an increasing discussion regarding the change of the prostacyclin/thromboxane ratio as an aetiological factor of pregnancy-induced hypertension (PIH). By means of videophotometric capillaroscopy in the capillaries of the nailfold, it is possible to visualise the resulting changes in the microcirculation. This method employs a special illumination microscope (magnification of the optical system x 560). Red blood cell velocity is measured under test conditions and microcirculatorical reaction capacity on ischaemic stress. Studies were conducted on healthy non-pregnant women and on healthy pregnant women as well as on patients suffering from pregnancy-induced hypertension. A markedly reduced velocity of red blood cells in patients with pregnancy-induced hypertension was seen as a sign of vasoconstriction, namely, 0.53 mm/sec. versus 0.74 mm/sec. Furthermore, these patients have a higher reactivity to ischaemic stress, probably also as a result of the already existing vasoconstriction; however, the duration of the hyperaemic phases is reduced in pregnancy-induced hypertension. By this method, an insight can be gained into microcirculation in pregnancy and in pregnancy-induced hypertension. In addition, as preliminary studies have already shown, the influence exercised by different medications on microcirculation can be assessed.

Capillary Microscopic and Rheological Dimensions for the Diagnosis of von Willebrand Disease in Comparison to other Haemorrhagic Diatheses

“…The earlier described capillary alteration for patients with vWD (types 1 and 2A) thanks to the present examination could be confirmed and quantified. The morphology changes of the capillaries especially with the capillary dilatation (median: 16.5 µm), extravasates (microscopic bleedings -median: 40%) and a higher grade of torquation (dysplasiamedian index: 3.5) of the nailfold capillaries have neither been seen at healthy individuals nor at patients with other haemorrhagic diathesis, who came for consultation at our haemostasiological outpatients clinics (31)(32)(33)(34)(35)(36).…”